Low dose of isotretinoin: A comprehensive review.

Autor: Abdelmaksoud A; Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt., Lotti T; Department of Dermatology, University of Rome 'G.Marconi', Rome, Italy., Anadolu R; Department of Dermatology, Venerology and Dermatopathology, International Dermatology, Dermatopathology, Esthetics and Anti-aging Academy (IDEA), Istanbul, Turkey.; Dermatology Clinic, Ankara, Turkey.; Faculty of Medicine, Department of Dermatology, Ankara University, Ankara, Turkey., Goldust M; University of Rome G. Marconi, Rome, Italy.; Department of Dermatology, University Medical Center Mainz, Mainz, Germany.; Department of Dermatology, University Hospital Basel, Basel, Switzerland., Ayhan E; Department of Dermatology, University of Health Sciences, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey., Dave DD; Dave Skin and Laser Clinic, Patan, Gujarat, India., Vestita M; Unit of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ebik B; Division of Gastroenterology Diyarbakir, Dicle University Faculty of Medicine, Kıtılbıl, Turkey., Gupta M; Treatwell Skin Centre, Jammu, India.
Jazyk: angličtina
Zdroj: Dermatologic therapy [Dermatol Ther] 2020 Mar; Vol. 33 (2), pp. e13251. Date of Electronic Publication: 2020 Feb 20.
DOI: 10.1111/dth.13251
Abstrakt: Isotretinoin is a first-generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti-inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date-unlimited PubMed search, from inception till December 2019, using the following search terms: "low-dose isotretinoin" and "dermatology," "isotretinoin and safety," "isotretinoin, off-label uses," "isotretinoin and male fertility," "isotretinoin, iPLEDGE system," aiming to deliver a therapeutic update relevant to clinical practice. All English-language articles were considered with no limitation based on the articles' type. Low-dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.
(© 2020 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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