Tranexamic acid is toxic on human chondrocytes, in vitro .

Autor: Jacob B; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Kloss N; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Böhle S; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Kirschberg J; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Zippelius T; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Heinecke M; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Matziolis G; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany., Röhner E; Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany.
Jazyk: angličtina
Zdroj: Journal of orthopaedics [J Orthop] 2019 Dec 19; Vol. 20, pp. 1-5. Date of Electronic Publication: 2019 Dec 19 (Print Publication: 2020).
DOI: 10.1016/j.jor.2019.12.008
Abstrakt: The aim of this study was to examine toxic effects of tranexamic acid (TXA) on the viability of human chondrocytes. Our hypothesis was that TXA damages human chondrocytes. Chondrocytes were cultured from donated human knee joints. TXA was added to these cultures. Toxicity were analyzed by using LDH und XTT Elisa assays, light microscopy and fluorescence microscopy. The results show that TXA damages human chondrocytes in vitro . We cannot recommend the use of TXA in hemiarthroplasty of the hip or unicompartmental knee arthroplasty in higher concentrations.
Competing Interests: None.
(© 2019 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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