Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle-Based Anticancer Drug.

Autor: Mai NXD; Center for Innovative Materials and Architectures (INOMAR), Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, 721337, Vietnam.; Faculty of Physics and Engineering Physics, University of Science, Vietnam National University, Ho Chi Minh City, 700000, Vietnam., Birault A; Institute for Integrated Cell-Material Sciences (ICeMS), Institute for Advanced Study Kyoto University, Kyoto, 606 8501, Japan., Matsumoto K; Institute for Integrated Cell-Material Sciences (ICeMS), Institute for Advanced Study Kyoto University, Kyoto, 606 8501, Japan., Ta HKT; Center for Innovative Materials and Architectures (INOMAR), Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, 721337, Vietnam.; Faculty of Materials Science and Technology, University of Science, Vietnam National University, Ho Chi Minh City, 700000, Vietnam., Intasa-Ard SG; Institute for Integrated Cell-Material Sciences (ICeMS), Institute for Advanced Study Kyoto University, Kyoto, 606 8501, Japan., Morrison K; TAE Life Sciences, Drug Development Division, Santa Monica, CA, 90404, USA., Thang PB; Center for Innovative Materials and Architectures (INOMAR), Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, 721337, Vietnam., Doan TLH; Center for Innovative Materials and Architectures (INOMAR), Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, 721337, Vietnam., Tamanoi F; Institute for Integrated Cell-Material Sciences (ICeMS), Institute for Advanced Study Kyoto University, Kyoto, 606 8501, Japan.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2020 Apr 03; Vol. 15 (7), pp. 593-599. Date of Electronic Publication: 2020 Feb 11.
DOI: 10.1002/cmdc.201900595
Abstrakt: Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B-labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR-loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR-loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK.
(© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)
Databáze: MEDLINE
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