The occurrence and pattern of head and neck sarcomas: a comprehensive cancer center experience.

Autor: Moreira DGL; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil., da Silva LP; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil., de Morais EF; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil., Queiroz SIML; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil., de Moura Santos E; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil., de Souza LB; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil., de Almeida Freitas R; Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil. roseanafreitas@hotmail.com.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2020 May; Vol. 277 (5), pp. 1473-1480. Date of Electronic Publication: 2020 Feb 04.
DOI: 10.1007/s00405-020-05834-x
Abstrakt: Purpose: This study aimed to analyze the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas diagnosed in a reference center in the Brazilian Northeast.
Materials and Methods: This retrospective cohort study reviewed the clinical records of patients with head and neck sarcomas. Epidemiologic data consisted in clinical location, age, gender, histopathological diagnosis, clinical TNM staging and treatment. Outcome variables were local recurrence and survival. The statistical analyses were performed by a binary logistic regression analysis. The survival analysis was assessed through the Kaplan-Meier curve.
Results: Sixty-nine patients with head and neck sarcomas (male 39; female 30) were analyzed. The most common histologic subtypes were rhabdomyosarcoma, dermatofibrosarcoma, and pleomorphic sarcoma. The mean age of the patients at the time of diagnosis was 38.1 years old. A total of 31 patient died (sarcoma-related death) up to the end of the follow-up, with a mean follow-up rate of 1.63 years. A multivariate analysis revealed that anatomical site, treatment modality, histopathological diagnosis, and clinical stage of the disease were associated with specific survival, reaching statistical significance.
Conclusion: This study demonstrates the impact of important clinical-pathological parameters on the overall prognosis of head and neck sarcomas.
Databáze: MEDLINE
Externí odkaz: