Endocrinopathies complicating transfusion-dependent hemoglobinopathy.
| Autor: | Al-Agha AE; Department of Paediatric Endocrinology, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail. aagha@kau.edu.sa., Bawahab NS, Nagadi SA, Alghamdi SA, Felemban DA, Milyani AA |
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| Jazyk: | angličtina |
| Zdroj: | Saudi medical journal [Saudi Med J] 2020 Feb; Vol. 41 (2), pp. 138-143. |
| DOI: | 10.15537/smj.2020.2.24845 |
| Abstrakt: | Objectives: To investigate the prevalence and significance of different endocrinopathies in children and adolescents with transfusion-dependent thalassemia and sickle-cell anemia. Methods: This is a descriptive, retrospective study between January 2010 and July 2018 in King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Data was collected through reviewing electronic hospital medical records then filling out data collection sheets and was interpreted through the IBM SPSS Statistics for Windows version 20.0 (IBM Corp, Armonk, NY, USA). Results: The total sample size was 119 patients, gender equality was almost achieved with 55.5% being male and 45.5% being female. The most common endocrinopathies were identified in the following order of short stature (39.5%), diabetes mellitus (29.4%), hypogonadism (12.6%), osteopenia (12.6%), osteoporosis (9.2%), hypothyroidism (9.2%), hypocortisolism (3.4%), and hypoparathyroidism (2.5%). All of which were statistically significant in their relationship to hemoglobinopathies with the exception of osteopenia and osteoporosis. Hypogonadism and hypocortisolism were found to be statistically significant in their relationship to a positive history of splenectomy at p=0.026 and p=0.012. Short stature was found to be statistically significant in its relationship to the male gender with a p=0.001. Conclusion: Endocrinopathy is a frequent complication of hemoglobinopathies, for which the most common were found to be short stature, diabetes mellitus, and low bone mineral density. |
| Databáze: | MEDLINE |
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