The Non-Coding RNA Landscape of Plasma Cell Dyscrasias.

Autor: Morelli E; Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Gullà A; Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Rocca R; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Federico C; Department of Radiation Oncology, Cancer Biology Division, Washington University in St. Louis School of Medicine, St. Louis, MO 63108, USA., Raimondi L; IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy., Malvestiti S; Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Agosti V; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.; Interdepartmental Center of Services (CIS) of Genomics, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Rossi M; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Costa G; Department of Health Science, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Giavaresi G; IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy., Azab KA; Department of Radiation Oncology, Cancer Biology Division, Washington University in St. Louis School of Medicine, St. Louis, MO 63108, USA., Cagnetta A; IRCCS, Ospedale Policlinico San Martino, 16100 Genoa, Italy.; Chair of Hematology, Department of Internal Medicine (DiMI), University of Genoa, 16100 Genoa, Italy., Cea M; IRCCS, Ospedale Policlinico San Martino, 16100 Genoa, Italy.; Chair of Hematology, Department of Internal Medicine (DiMI), University of Genoa, 16100 Genoa, Italy., Tagliaferri P; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Neri A; Department of Oncology and Hemato-oncology, University of Milan and Hematology, Fondazione Cà Granda IRCCS Policlinico, 20122 Milan, Italy., Munshi NC; Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Viglietto G; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Tassone P; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy., Amodio N; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2020 Jan 30; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 30.
DOI: 10.3390/cancers12020320
Abstrakt: Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.
Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Databáze: MEDLINE
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