Reversed Cation Selectivity of G 8 -Octamer and G 16 -Hexadecamer towards Monovalent and Divalent Cations.

Autor: He Y; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida, 33620, United States., Zhang Y; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China., Wojtas L; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida, 33620, United States., Akhmedov NG; Department of Chemistry, West Virginia University, Morgantown, WV, 26505, United States., Pan Q; Key Laboratory of Advanced Materials of Tropical Island Resources, Hainan University, Haikou, 570228, P. R. China., Guo H; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China., Shi X; Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida, 33620, United States.
Jazyk: angličtina
Zdroj: Chemistry, an Asian journal [Chem Asian J] 2020 Apr 01; Vol. 15 (7), pp. 1030-1034. Date of Electronic Publication: 2020 Mar 06.
DOI: 10.1002/asia.202000016
Abstrakt: A reverse-binding-selectivity between monovalent and divalent cations was observed for two different self-assembly G 16 -hexadecamer and G 8 -octamer systems. The dissociation constant between G 4 -quadruplex and monomer was calculated via VT- 1 H NMR experiments. Quantitative energy profiles revealed entropy as the key factor for the weaker binding toward Ba 2+ compared with K + in the G 8 -octamer system despite stronger ion-dipole interactions. This study is the first direct comparison of the G 4 -quartet binding affinity between mono and divalent cations and will benefit future applications of G-quadruplex-related research. Further competition experiments between the G 8 -octamer and 18-crown-6 with K + demonstrated the potential of this G 8 system as a new potassium receptor.
(© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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