Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test.
Autor: | Beyene HB; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Hamley S; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia., Giles C; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Huynh K; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Smith A; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Cinel M; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Mellet NA; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Morales-Scholz MG; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia., Kloosterman D; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia., Howlett KF; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia., Kowalski GM; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia., Shaw CS; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Science, Deakin University, Melbourne, Victoria, Australia., Magliano DJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Bruce CR; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia. |
---|---|
Jazyk: | angličtina |
Zdroj: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Mar 01; Vol. 105 (3). |
DOI: | 10.1210/clinem/dgaa054 |
Abstrakt: | Context: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and better understand mechanisms of IR associated with abnormal lipid metabolism. Objective: The objective of this article is to determine plasma lipid species associated with indices of IR and evaluate the lipidome response to an oral glucose tolerance test (OGTT). Design and Setting: This study was community based and cross-sectional. Participants and Sample: Plasma samples (collected at 0 and 120 min during an OGTT) from nonobese, young adults age 18 to 34 years (n = 246) were analyzed using liquid chromatography-tandem mass spectrometry. Main Outcome Measures: The associations between indices of IR and lipid classes and species (with a sex interaction term), or changes in lipid levels during an OGTT, were tested using linear models (adjusted for age, sex, body mass index, total cholesterol, high-density lipoprotein cholesterol, and triglycerides). Results: Some (213) and (199) lipid species were associated with the homeostatic model assessment of insulin resistance and insulin area under curve (AUC), respectively. Alkylphosphatidylcholine (10), alkenylphosphatidylcholine (23), and alkylphosphatidylethanolamine (6) species were associated with insulin AUC in men only. Species of phosphatidylcholine (7) and sphingomyelin (5) were associated in women only. In response to an OGTT, a perturbation in the plasma lipidome, particularly in acylcarnitine species, was observed; and the changes in many lipid species were associated with insulin AUC. Conclusions: The plasma lipidome and changes in lipid levels during an OGTT were associated with indices of IR. These findings underlie the involvement of molecular lipid species in the pathogenesis of IR and possibly crosstalk between IR and sex-specific regulation of lipid metabolism. (© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
Databáze: | MEDLINE |
Externí odkaz: |