Early weaning leads to disruption of homeostatic and hedonic eating behaviors and modulates serotonin (5HT) and dopamine (DA) systems in male adult rats.

Autor: Tavares GA; Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil; Nantes Université, INRAE, UMR 1280, PhAN, F-44000, Nantes, France. Electronic address: gabrieltavaresufpe@outlook.com., do Amaral Almeida LC; Graduate Program of Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife, Brazil., de Souza JA; Graduate Program of Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife, Brazil., de Farias VV; Biosciences Center, Federal University of Pernambuco, Brazil., de Souza FL; Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil., de Andrade Silva SC; Graduate Program of Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife, Brazil., Lagranha CJ; Graduate Program of Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife, Brazil; Academic Center of Vitória (CAV), Federal University of Pernambuco, Vitoria de Santo Antão, Brazil., Kaeffer B; Nantes Université, INRAE, UMR 1280, PhAN, F-44000, Nantes, France., de Souza SL; Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil; Graduate Program of Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco, Recife, Brazil.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2020 Apr 06; Vol. 383, pp. 112531. Date of Electronic Publication: 2020 Jan 31.
DOI: 10.1016/j.bbr.2020.112531
Abstrakt: Early weaning is associated with disruption of eating behavior. However, little is known about the mechanisms behind it. 5HT and DA systems are key regulators of homeostatic and hedonic eating behaviors, respectively. Thus, this study aims to evaluate the effects of early weaning on feeding behavior and 5HT and DA systems. For this, rats were submitted to regular (PND30) or early weaning (PND15) and between PND250 and PND300 were evaluated food intake of standard diet in response to 4 h food deprivation, during the 24 h period and per phase of the circadian cycle, in addition to the palatable food intake. Additionally, body mass and mRNA expression of 5HT1B, 5HT2C, SERT, DRD1 and DRD2 were evaluated in the hypothalamus and brainstem. The results demonstrate that early weaning promoted an increase in standard food intake in response to a 4 h food deprivation in the 24 h period and in the dark phase of the circadian cycle, in addition to an increased palatable food intake. No differences in body mass between regular or early weaning were observed. In the hypothalamus, increased mRNA expression of SERT and DRD1 was observed, but decreased 5HT1B mRNA expression. In the brainstem, the expression of 5HT1B, SERT, 5HT2C, DRD1 and DRD2 was increased in early weaned rats. In a nutshell, the stress promoted by early weaning has programmed the animals to be hyperphagic and to increase their palatable food intake, which was associated with modulation of 5HT and DA systems.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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