Exploring the determinants of the cardiac changes after ultra-long duration exercise: The echocardiographic Spartathlon study.

Autor:	Christou GA; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Pagourelias ED; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Anifanti MA; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Sotiriou PG; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Koutlianos NA; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Tsironi MP; Department of Nursing, Faculty of Human Movement and Quality of Life Sciences, University of Peloponnese, Sparta, Greece., Andriopoulos PI; Department of Nursing, Faculty of Human Movement and Quality of Life Sciences, University of Peloponnese, Sparta, Greece., Christou KA; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Kouidi EJ; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece., Deligiannis AP; Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Greece.
Jazyk:	angličtina
Zdroj:	European journal of preventive cardiology [Eur J Prev Cardiol] 2020 Sep; Vol. 27 (14), pp. 1467-1477. Date of Electronic Publication: 2020 Feb 03.
DOI:	10.1177/2047487319898782
Abstrakt:	Aim: The investigation of the pathophysiological determinants of cardiac changes following ultra-long duration exercise. Methods: Twenty-seven runners who finished a 246 km running race were examined both before and after the finish of the race. Examinations included echocardiography and measurement of body weight and blood biochemical parameters. Results: Exercise increased left ventricular end-diastolic interventricular septum thickness (LVIVSd) ( p  < 0.001) and posterior wall thickness (LVPWTd) ( p  = 0.001) and right ventricular end-diastolic area ( p  = 0.005), while reduced tricuspid annular plane systolic excursion (TAPSE) ( p  = 0.004). A minor decrease in the peak absolute values of both left ventricular (from -20.9 ± 2.3% to -18.8 ± 2.0%, p  = 0.009) and right ventricular (from -22.9 ± 3.6% to -21.2 ± 3.0%, p  = 0.040) global longitudinal strains occurred. There was decrease in body weight ( p  < 0.001) and increase in both circulating high-sensitivity troponin I ( p  = 0.028) and amino-terminal pro-B type natriuretic peptide (NT-proBNP) ( p  = 0.018). The change in the sum of LVIVSd and LVPWTd correlated negatively with percentage change of body weight ( r  = -0.416, p  = 0.049). The only independent determinant of post-exercise NT-proBNP was pulmonary artery systolic pressure ( r  = 0.797, p  = 0.002). Post-exercise NT-proBNP correlated positively with percentage changes of basal (RVbas) ( r  = 0.582, p  = 0.037) and mid-cavity (RVmid) ( r  = 0.618, p  = 0.043) right ventricular diameters and negatively with percentage change of TAPSE ( r  = -0.720, p  = 0.008). Similar correlations with RVbas, RVmid and TAPSE were found for pulmonary artery systolic pressure. Post-exercise high-sensitivity troponin I correlated negatively with percentage change of body weight ( r  = -0.601, p  = 0.039), but was not associated with any cardiac parameter. Conclusion: The main cardiac effects of ultra-long duration exercise were the decrease in left ventricular end-diastolic dimensions and increase in left ventricular wall thickness, as well as minimal dilatation and alteration in systolic function of right ventricle, possibly due to the altered exercise-related right ventricular afterload.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu