| Autor: |
Pieczynska MD; Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A Street, 05-552 Jastrzebiec, Poland.; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5A Street, 02-106 Warsaw, Poland., Yang Y; Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A Street, 05-552 Jastrzebiec, Poland.; Institute of Clinical Chemistry, University Hospital Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland., Petrykowski S; Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A Street, 05-552 Jastrzebiec, Poland., Horbanczuk OK; Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159c Nowoursynowska, 02-776 Warsaw, Poland., Atanasov AG; Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A Street, 05-552 Jastrzebiec, Poland.; Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria.; Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev str., 1113 Sofia, Bulgaria.; Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria., Horbanczuk JO; Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A Street, 05-552 Jastrzebiec, Poland. |
| Abstrakt: |
Gut microbiota metabolites have a great influence on host digestive function and body health itself. The effects of intestinal microbes on the host metabolism and nutrients absorption are mainly due to regulatory mechanisms related to serotonin, cytokines, and metabolites. Multiple studies have repeatedly reported that the gut microbiota plays a fundamental role in the absorption of bioactive compounds by converting dietary polyphenols into absorbable bioactive substances. Moreover, some intestinal metabolites derived from natural polyphenol products have more biological activities than their own fundamental biological functions. Bioactive like polyphenolic compounds, prebiotics and probiotics are the best known dietary strategies for regulating the composition of gut microbial populations or metabolic/immunological activities, which are called "three "p" for gut health". Intestinal microbial metabolites have an indirect effect on atherosclerosis, by regulating lipid metabolism and inflammation. It has been found that the diversity of intestinal microbiota negatively correlates with the development of atherosclerosis. The fewer the variation and number of microbial species in the gut, the higher the risk of developing atherosclerosis. Therefore, the atherosclerosis can be prevented and treated from the perspective of improving the number and variability of gut microbiota. In here, we summarize the effects of gut metabolites of natural products on the pathological process of the atherosclerosis, since gut intestinal metabolites not only have an indirect effect on macrophage foaming in the vessel wall, but also have a direct effect on vascular endothelial cells. |
