Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer.

Autor: Mazzoldi EL; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.; Current address: Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy., Pastò A; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.; Current address: Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, 20089 Milan, Italy., Pilotto G; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy., Minuzzo S; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy., Piga I; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy., Palumbo P; Medical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy., Carella M; Medical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy., Frezzini S; Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy., Nicoletto MO; Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy., Amadori A; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy., Indraccolo S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2020 Jan 29; Vol. 9 (2). Date of Electronic Publication: 2020 Jan 29.
DOI: 10.3390/jcm9020368
Abstrakt: The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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