Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location.

Autor:	Sarkander J; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Hojyo S; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Mursell M; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Yamasaki Y; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Wu TY; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Tumes DJ; Centre for Cancer Biology, SA Pathology and The University of South Australia, Adelaide, SA, Australia., Miyauchi K; Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Tran CL; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Zhu J; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Löhning M; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany.; Experimental Immunology and Osteoarthritis Research, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Hutloff A; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Mashreghi MF; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Kubo M; Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Division of Molecular Pathology, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan., Radbruch A; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany., Tokoyoda K; Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Berlin, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2020 Jan 15; Vol. 10, pp. 3113. Date of Electronic Publication: 2020 Jan 15 (Print Publication: 2019).
DOI:	10.3389/fimmu.2019.03113
Abstrakt:	CD4 T cell memory is fundamental for long-lasting immunity and effective secondary responses following infection or vaccination. We have previously found that memory CD4 T cells specific for systemic antigens preferentially reside in the bone marrow (BM) and arise from splenic CD49b + T-bet + CD4 T cells. However, how BM-homing memory precursors are generated during an immune reaction is unknown. We show here that BM memory precursors are generated via augmented rates of cell division throughout a primary immune response. Treatment with the cytostatic drug cyclophosphamide or blockade of the CD28/B7 co-stimulatory pathway at the beginning of the contraction phase abrogates the generation of BM memory precursors. We determine that, following a critical number of cell divisions, memory precursors downregulate CCR7 and upregulate IL-2Rβ, indicating that loss of CCR7 and gain of IL-2 signal are required for the migration of memory precursors toward the BM. (Copyright © 2020 Sarkander, Hojyo, Mursell, Yamasaki, Wu, Tumes, Miyauchi, Tran, Zhu, Löhning, Hutloff, Mashreghi, Kubo, Radbruch and Tokoyoda.)
Databáze:	MEDLINE
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