Smoothed Particle Hydrodynamics multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets.

Autor: Sibilla S; Dipartimento di Ingegneria Civile e Architettura, Università di Pavia, via Ferrata 3, 27100 Pavia, Italy. Electronic address: stefano.sibilla@unipv.it., Manenti S; Dipartimento di Ingegneria Civile e Architettura, Università di Pavia, via Ferrata 3, 27100 Pavia, Italy., Cazzato T; Dipartimento di Elettronica, Informazione e Bioingegneria Politecnico di Milano, via Ponzio 34/5, 20133 Milano, Italy., Colombo F; Dipartimento di Elettronica, Informazione e Bioingegneria Politecnico di Milano, via Ponzio 34/5, 20133 Milano, Italy., Tomei AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL 33136-1011, USA; Department of Biomedical Engineering, University of Miami, 1251 Memorial Drive, McArthur Engineering Building, Coral Gables, FL 33146, USA., Redaelli A; Dipartimento di Elettronica, Informazione e Bioingegneria Politecnico di Milano, via Ponzio 34/5, 20133 Milano, Italy., Manzoli V; Dipartimento di Elettronica, Informazione e Bioingegneria Politecnico di Milano, via Ponzio 34/5, 20133 Milano, Italy; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL 33136-1011, USA., Consolo F; Dipartimento di Elettronica, Informazione e Bioingegneria Politecnico di Milano, via Ponzio 34/5, 20133 Milano, Italy; Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy.
Jazyk: angličtina
Zdroj: Medical engineering & physics [Med Eng Phys] 2020 Mar; Vol. 77, pp. 19-30. Date of Electronic Publication: 2020 Jan 31.
DOI: 10.1016/j.medengphy.2020.01.004
Abstrakt: The paper discusses a Smoothed Particle Hydrodynamics (SPH) model for the analysis of the multiphase flow occurring in an experimental microfluidic device for conformal coating of pancreatic islets with a biocompatible and permeable polymer. The proposed numerical model, based on a weakly-compressible SPH approach, accurately mimics the encapsulation process while assuring phase conservation, thus overcoming potential limitations of grid-based models. The proposed SPH model is a triphasic multi-phase model that allows one: (i) to reproduce the physics of islet conformal coating, including the effects of surface tension at the interface of the involved fluids and of the islet diameter; and (ii) to evaluate how modulation of process parameters influences the fluid dynamics within the microfluidic device and the resulting coating characteristics. This model can represent a valuable, time- and cost-effective tool for the definition of optimized encapsulation conditions through in silico screening of novel combinations of conformal coating parameters, including polymeric coating blends, size range of insulin-secreting cell clusters, utilized chemical reagents, device geometry and scale.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020 IPEM. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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