Minimal immune response to booster vaccination against Yellow Fever associated with pre-existing antibodies.

Autor: Bovay A; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland., Nassiri S; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland; Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland., Maby-El Hajjami H; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland., Marcos Mondéjar P; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland., Akondy RS; Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA., Ahmed R; Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA., Lawson B; Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA., Speiser DE; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland., Fuertes Marraco SA; Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland. Electronic address: silvia.fuertesmarraco@unil.ch.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2020 Feb 24; Vol. 38 (9), pp. 2172-2182. Date of Electronic Publication: 2020 Jan 31.
DOI: 10.1016/j.vaccine.2020.01.045
Abstrakt: Ever since its development in the 1930's, the live-attenuated Yellow Fever virus vaccine YF-17D has been highly effective. Despite the increasing knowledge on the immune biology of the YF-17D vaccine, most studies have focused only on a few types of immune cells and pathways or mainly on the primary adaptive immune response to YF-17D vaccination. Here, we examined humoral, innate and adaptive cellular responses in a longitudinal YF-17D vaccination study in Switzerland, comparing both primary and booster vaccination. In contrast to the strong innate and adaptive immune response to the primary vaccination, we find that the response to boosting is much reduced. Our data show an inverse association of neutralizing antibodies at baseline with vaccine virus replication and with the immune response upon boosting. These results suggest that booster vaccination may not have major immunological effects when neutralizing antibodies are present. Importantly, our study population was healthy adults in a non-endemic country and ultimately booster vaccine requirement must be assessed based on additional epidemiological and public health considerations in endemic areas.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: