Craving mediates the effect of impulsivity on lapse-risk during alcohol use disorder treatment.

Autor: Coates JM; Alcohol and Drug Assessment Unit, Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia; Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia; School of Psychology, The University of Queensland, Brisbane, Australia., Gullo MJ; Alcohol and Drug Assessment Unit, Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia; Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia., Feeney GFX; Alcohol and Drug Assessment Unit, Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia; Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia., McD Young R; Alcohol and Drug Assessment Unit, Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia; Faculty of Health, Queensland University of Technology, Brisbane, Australia., Dingle GA; Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia; School of Psychology, The University of Queensland, Brisbane, Australia., Clark PJ; Alcohol and Drug Assessment Unit, Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia., Connor JP; Alcohol and Drug Assessment Unit, Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia; Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Australia. Electronic address: jason.connor@uq.edu.au.
Jazyk: angličtina
Zdroj: Addictive behaviors [Addict Behav] 2020 Jun; Vol. 105, pp. 106286. Date of Electronic Publication: 2020 Jan 02.
DOI: 10.1016/j.addbeh.2019.106286
Abstrakt: Rash impulsiveness, the propensity for approach behaviour despite potential negative consequences, is associated with stronger alcohol craving in patients with Alcohol Use Disorder (AUD). This relationship is poorly understood and implications for treatment response are unexamined. This study explored the relationship between rash impulsiveness, craving, and treatment response among 304 outpatients enrolled in a 12-week abstinence-based Cognitive-Behavioural Therapy (CBT) program for AUD. Assessments were completed pre-and-post treatment, with craving and alcohol consumption monitored at each treatment session. Higher rash impulsiveness predicted more frequent craving over treatment (b = 0.95, 95% CI = 0.40, 1.50). Higher craving was associated with greater lapse-risk (b = 0.04, 95% CI = 0.03, 0.05), with the association between craving and lapse-risk increasing as treatment progressed (b = 0.01, 95% CI = 0.01, 0.02). Craving positively mediated the relationship between rash impulsiveness and lapse-risk (µ = 0.38, 95% CI = 0.10, 0.70). Contrary to hypotheses, the risk of lapse in response to craving was not moderated by rash-impulsiveness. These results suggest that AUD patients with a predisposition for rash impulsiveness are more vulnerable to alcohol craving, and subsequently, poorer treatment outcomes.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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