Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility.

Autor: Montefusco-Pereira CV; Department of Drug Delivery (DDEL), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, Saarbrücken 66123, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. Electronic address: carlos.montefusco@helmholtz-hips.de., Formicola B; School of Medicine and Surgery, Nanomedicine Center NANOMIB, University of Milano-Bicocca (UNIMIB), Via Raoul Follereau 3, 20854 Vedano al Lambro (MB), Italy. Electronic address: b.formicola@campus.unimib.it., Goes A; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany; Biogenic Nanotherapeutics Group (BION), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, Saarbrücken 66123, Germany. Electronic address: adriely.goes@helmholtz-hips.de., Re F; School of Medicine and Surgery, Nanomedicine Center NANOMIB, University of Milano-Bicocca (UNIMIB), Via Raoul Follereau 3, 20854 Vedano al Lambro (MB), Italy. Electronic address: francesca.re1@unimib.it., Marrano CA; School of Medicine and Surgery, Nanomedicine Center NANOMIB, University of Milano-Bicocca (UNIMIB), Via Raoul Follereau 3, 20854 Vedano al Lambro (MB), Italy. Electronic address: claudia.marrano@unimib.it., Mantegazza F; School of Medicine and Surgery, Nanomedicine Center NANOMIB, University of Milano-Bicocca (UNIMIB), Via Raoul Follereau 3, 20854 Vedano al Lambro (MB), Italy. Electronic address: francesco.mantegazza@unimib.it., Carvalho-Wodarz C; Department of Drug Delivery (DDEL), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, Saarbrücken 66123, Germany. Electronic address: cristiane.carvalho@helmholtz-hips.de., Fuhrmann G; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany; Biogenic Nanotherapeutics Group (BION), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, Saarbrücken 66123, Germany. Electronic address: gregor.fuhrmann@helmholtz-hips.de., Caneva E; UNITECH COSPECT: Comprehensive Substances characterization via advanced sPECTtrometry, 20133 Milan, Italy. Electronic address: enrico.caneva@unimi.it., Nicotra F; Bio Organic Chemistry Laboratory, Department of Biotechnology and Biosciences, University of Milan - Bicocca (UNIMIB), Piazza della Scienza 2, 20126 Milan, Italy. Electronic address: francesco.nicotra@unimib.it., Lehr CM; Department of Drug Delivery (DDEL), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, Saarbrücken 66123, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. Electronic address: claus-michael.lehr@helmholtz-hips.de., Russo L; Bio Organic Chemistry Laboratory, Department of Biotechnology and Biosciences, University of Milan - Bicocca (UNIMIB), Piazza della Scienza 2, 20126 Milan, Italy. Electronic address: laura.russo@unimib.it.
Jazyk: angličtina
Zdroj: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2020 Apr; Vol. 149, pp. 12-20. Date of Electronic Publication: 2020 Jan 31.
DOI: 10.1016/j.ejpb.2020.01.013
Abstrakt: By functionalizing the surface of PEG-liposomes with linkers bearing quaternary ammonium compounds (QACs), we generated novel bacteria disruptors with anti-adhesive properties and reduced cytotoxicity compared to free QACs. Furthermore, QAC-functionalized liposomes are a promising platform for future drug encapsulation. The QAC (11-mercaptoundecyl)-N,N,N-trimethylammonium bromide (MTAB) was attached to maleimide-functionalized liposomes (DSPE-PEG) via thiol linker. The MTAB-functionalized liposomes were physicochemically characterized and their biological activity, in terms of anti-adherence activity and biofilm prevention in Escherichia coli were assessed. The results showed that MTAB-functionalized liposomes inhibit bacterial adherence and biofilm formation while reducing MTAB toxicity.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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