| Autor: |
Muraina IA; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria., Gotep JG; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria., Tanko JT; Parasitology Division, National Veterinary Research Institute, Vom, Nigeria., Onyiche TE; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria. et.onyiche@unimaid.edu.ng.; Department of Veterinary Parasitology and Entomology, University of Maiduguri, Maiduguri, Nigeria. et.onyiche@unimaid.edu.ng.; Unit for Environmental Sciences and Management, North West University, Potchefstroom Campus, Private Bag X6001, Potchefstroom, 2520, South Africa. et.onyiche@unimaid.edu.ng., Aladelokun OB; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria.; Center for Molecular Oncology, University of Connecticut Health, Farmington, CT, USA., Dapuliga CC; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria.; Department of Microbiology Department, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Forcados GE; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria., Ozele N; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria., Samuel AL; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria., Oladipo OO; Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria., Akanbi OB; Central Diagnostics Laboratory, National Veterinary Research Institute, Vom, PMB 01, Nigeria.; Department of Veterinary Pathology, University of Ilorin, Ilorin, Nigeria., Okewole PA; Central Diagnostics Laboratory, National Veterinary Research Institute, Vom, PMB 01, Nigeria., Ahmed MS; National Veterinary Research Institute, Vom, Nigeria. |
| Abstrakt: |
Graded concentrations (200, 400 and 800 mg/kg) of the aqueous stem bark extract of Khaya senegalensis was evaluated for its therapeutic efficacy against experimentally induced coccidiosis in broiler chicken. The phytochemical analysis shows the presence of tannins, saponins, cardiac glycosides and steroids. There was significant reduction in oocyst count across the groups in a graded dose manner with 800 mg/kg being the most efficacious dose. There was also weight gain across the treatment groups with immuno-modulatory and erythropoetic activities observed. Also, a significant (p < 0.05) graded dose-dependent reduction in the oocyst count in the treatment groups. A significant (p < 0.05) increase in mean weight gain was also recorded across the experimental groups except the negative control. The haematology also showed a dose-dependent increase in red blood cells, haemoglobin and packed cell volume of the treatment groups. The extract had no significant difference (p > 0.05) on the white blood cells, but a slight decrease in the white blood cells and heterophil counts was observed at 400 mg/kg. Furthermore, the aspartate amino transaminase level showed a significant difference (p < 0.05). Fluctuating levels of other serum biochemical parameters such as total protein, albumin and potassium were observed. No significant difference (p > 0.05) in the sodium concentration was observed. In addition, oxidative stress biomarkers such as catalase significantly increased (p < 0.05) in all the experimental groups in addition to the concomitant increase in reduced gluthathione (GSH) and superoxide dismutase (SOD) levels. Conclusively, the aqueous extract of K. senegalensis was effective in the management of coccidiosis thus supporting its folkloric use. |
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