| Autor: |
Lex TR; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Brummel BR; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Attia MF; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA.; Department of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC, 29634, USA., Giambalvo LN; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Lee KG; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Van Horn BA; Department of Chemistry and Biochemistry, College of Charleston, 66 George St., Charleston, SC, 29414, USA., Whitehead DC; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA. dwhiteh@clemson.edu., Alexis F; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA. falexis@yachaytech.edu.ec.; School of Biological Sciences and Engineering, Yachay Tech, San Miguel de Urcuquí, Ecuador. falexis@yachaytech.edu.ec. |
| Abstrakt: |
Synthetic materials exhibiting contrast imaging properties have become vital to the field of biomedical imaging. However, polymeric biomaterials are lacking imaging contrast properties for deep tissue imaging. This report details the synthesis and characterization of a suite of aryl-iodo monomers, which were used to prepare iodinated polyesters using a pre-functionalization approach. Commercially available 4-iodo-phenylalanine or 4-iodobenzyl bromide served as the starting materials for the synthesis of three iodinated monomeric moieties (a modified lactide, morpholine-2,5-dione, and caprolactone), which under a tin-mediated ring-opening polymerization (ROP), generated their respective polyesters (PE) or poly(ester amides) (PEA). An increase in X-ray intensity of all synthesized iodine-containing polymers, in comparison to non-iodinated poly(lactic acid) (PLA), validated their functionality as radio-opaque materials. The iodinated-poly(lactic acid) (iPLA) material was visualized through varying thicknesses of chicken tissue, thus demonstrating its potenial as a radio-opaque biomaterial. |
