Nonmedical Factors and Health-Related Quality of Life in CKD in India.

Autor:	Modi GK; Nephrology, Samarpan Kidney Institute and Research Center, Bhopal, India., Yadav AK; Departments of Experimental Medicine and Biotechnology and., Ghosh A; George Institute for Global Health, University of New South Wales, New Delhi, India., Kamboj K; Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Kaur P; Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Kumar V; Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Bhansali S; Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Prasad N; Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India., Sahay M; Department of Nephrology, Osmania Medical College, Osmania General Hospital, Hyderabad, India., Parameswaran S; Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Varughese S; Department of Nephrology, Christian Medical College, Vellore, India., Gang S; Department of Nephrology, Muljibhai Patel Urological Hospital, Nadiad, India., Singh S; Department of Nephrology, Institute of Medical Science, Banaras Hindu University, Varanasi, India., Sircar D; Department of Nephrology, Institute of Post Graduate Medical Education and Research, Kolkata, India., Gopalakrishnan N; Department of Nephrology, Rajiv Gandhi Government General Hospital, Chennai, India., Jaryal A; Department of Nephrology, Indira Gandhi Medical College, Shimla, India., Vikrant S; Department of Nephrology, Indira Gandhi Medical College, Shimla, India., Agarwal SB; Department of Nephrology and Transplant Center, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden., Jha V; George Institute for Global Health, University of New South Wales, New Delhi, India.; Manipal Academy of Higher Education, Manipal, Karnataka, India; and.; University of Oxford, Oxford, United Kingdom.
Jazyk:	angličtina
Zdroj:	Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2020 Feb 07; Vol. 15 (2), pp. 191-199. Date of Electronic Publication: 2020 Jan 30.
DOI:	10.2215/CJN.06510619
Abstrakt:	Background and Objectives: Patient-reported outcomes have gained prominence in the management of chronic noncommunicable diseases. Measurement of health-related quality of life is being increasingly incorporated into medical decision making and health care delivery processes. Design, Setting, Participants, & Measurements: The Indian Chronic Kidney Disease Study is a prospective cohort of participants with mild to moderate CKD. Baseline health-related quality of life scores, determined by the standardized Kidney Disease Quality of Life 36 item instrument, are presented for the inception cohort ( n =2919). Scores are presented on five subscales: mental component summary, physical component summary, burden, effect of kidney disease, and symptom and problems; each is scored 0-100. The associations of socioeconomic and clinical parameters with the five subscale scores and lower quality of life (defined as subscale score <1 SD of the sample mean) were examined. The main socioeconomic factors studied were sex, education, occupation, and income. The key medical factors studied were age, eGFR, diabetes, hypertension, and albuminuria. Results: The mean (SD) subscale scores were physical component summary score, 43±9; mental component summary score, 48±10; burden, 61±33; effects, 87±13; and symptoms, 90±20. Among the socioeconomic variables, women, lower education, and lower income were negatively associated with reduced scores across all subscales. For instance, the respective β -coefficients (SD) for association with the physical component summary subscale were -2.6 (-3.4 to -1.8), -1.5 (-2.2 to -0.7), and -1.6 (-2.7 to -0.5). Medical factors had inconsistent or no association with subscale scores. The quality of life scores also displayed regional variations. Conclusions: In this first of its kind analysis from India, predominantly socioeconomic factors were associated with quality of life scores in patients with CKD. (Copyright © 2020 by the American Society of Nephrology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu