Lycopene and bone: an in vitro investigation and a pilot prospective clinical study.

Autor: Russo C; Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, 88100, Catanzaro, Italy., Ferro Y; Department of Health Science, University Magna Graecia, 88100, Catanzaro, Italy., Maurotti S; Department of Medical and Surgical Science, University Magna Graecia, 88100, Catanzaro, Italy., Salvati MA; Department of Medical and Surgical Science, University Magna Graecia, 88100, Catanzaro, Italy., Mazza E; Department of Medical and Surgical Science, University Magna Graecia, 88100, Catanzaro, Italy., Pujia R; Department of Medical and Surgical Science, University Magna Graecia, 88100, Catanzaro, Italy., Terracciano R; Department of Health Science, University Magna Graecia, 88100, Catanzaro, Italy., Maggisano G; Department of Health Science, University Magna Graecia, 88100, Catanzaro, Italy., Mare R; Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, 88100, Catanzaro, Italy., Giannini S; Department of Medicine, Clinica Medica 1, University of Padova and Regional Centre for Osteoporosis, Padua, Italy., Romeo S; Department of Medical and Surgical Science, University Magna Graecia, 88100, Catanzaro, Italy.; Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, 42246, Göteborg, Sweden., Pujia A; Department of Medical and Surgical Science, University Magna Graecia, 88100, Catanzaro, Italy., Montalcini T; Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, 88100, Catanzaro, Italy. tmontalcini@unicz.it.
Jazyk: angličtina
Zdroj: Journal of translational medicine [J Transl Med] 2020 Jan 29; Vol. 18 (1), pp. 43. Date of Electronic Publication: 2020 Jan 29.
DOI: 10.1186/s12967-020-02238-7
Abstrakt: Background: There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects on bone are scarce. Our aim was to investigate the effects of lycopene on osteoblast cells as well as bone mineral density and bone turnover markers in postmenopausal women.
Methods: We investigated the effect of lycopene on the Wnt/β-catenin and ERK 1/2 pathways, RUNX2, alkaline phosphatase, RANKL and COL1A of Saos-2. We also carried out a pilot controlled clinical study to verify the feasibility of an approach for bone loss prevention through the intake of a lycopene-rich tomato sauce in 39 postmenopausal women.
Results: Lycopene 10 µM resulted in higher β-catenin and phERK1/2 protein Vs the vehicle (p = 0.04 and p = 0.006). RUNX2 and COL1A mRNA was induced by both 5 and 10 µM doses (p = 0.03; p = 0.03 and p = 0.03; p = 0.05) while RANKL mRNA was reduced (p < 0.05). A significant bone density loss was not detected in women taking the tomato sauce while the control group had bone loss (p = 0.002). Tomato sauce intake resulted in a greater bone alkaline phosphatase reduction than the control (18% vs 8.5%, p = 0.03).
Conclusions: Lycopene activates the WNT/β-catenin and ERK1/2 pathways, upregulates RUNX2, alkaline phosphatase, COL1A and downregulates RANKL Saos-2. These processes contributed to prevent bone loss in postmenopausal women.
Databáze: MEDLINE
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