Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results.

Autor:	Alterio D; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Tagliabue M; Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Muto M; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Zorzi S; Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Volpe S; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Gandini S; Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Sibio D; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Bayır Ö; Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Otolaryngology and Head and Neck Surgery, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey., Marvaso G; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Ferrari A; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Bruschini R; Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Cossu Rocca M; Medical Oncology Division of Urogenital and Head and Neck Tumours, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Preda L; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy.; Diagnostic Imaging Unit, National Center of Oncological Hadrontherapy (CNAO), Pavia, Italy., Marangoni R; Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Starzynska A; Department of Oral Surgery, Medical University of Gdansk, Gdansk, Poland., Vigorito S; Unit of Medical Physics, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Ansarin M; Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Jereczek-Fossa BA; Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Jazyk:	angličtina
Zdroj:	Tumori [Tumori] 2020 Dec; Vol. 106 (6), pp. 471-479. Date of Electronic Publication: 2020 Jan 30.
DOI:	10.1177/0300891619900920
Abstrakt:	Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN). Methods: We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded. Results: No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes ( p = 0.05). Conclusion: We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu