Salvage treatment of NSCLC recurrence after first-line chemotherapy failure: Iodine-125 seed brachytherapy or microwave ablation?
Autor: | Liu B; Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, PR China.; Interventional Oncology Institute of Shandong University, Jinan, China., Wang Y; Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, PR China.; Interventional Oncology Institute of Shandong University, Jinan, China., Tian S; School of Medicine, Shandong University, Jinan, China., Hertzanu Y; Department of Radiology, Ben-Gurion University, Negev, Israel., Zhao X; Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, PR China.; Department of Thoracic Surgery, The Second Hospital of Shandong University, Jinan, China., Li Y; Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, PR China.; Interventional Oncology Institute of Shandong University, Jinan, China. |
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Jazyk: | angličtina |
Zdroj: | Thoracic cancer [Thorac Cancer] 2020 Mar; Vol. 11 (3), pp. 697-703. Date of Electronic Publication: 2020 Jan 29. |
DOI: | 10.1111/1759-7714.13320 |
Abstrakt: | Background: Salvage treatments for recurrent NSCLC after first-line chemotherapy remain challenging. This study was conducted to evaluate the clinical value of microwave ablation (MWA) and iodine-125 brachytherapy, including overall survival (OS), disease free survival (DFS), local control, hospital stay, and health economics. Methods: The data of 51 and 32 patients who were treated with MWA and brachytherapy was retrospectively analyzed. The number of lesions was limited up to two, with a diameter <4 cm and patients diagnosed with unilateral lung disease. Peripheral tumors were treated with MWA, while lesions close to the hilum were treated with brachytherapy. Contrast-enhanced CT, blood cell count, coagulation function, liver & kidney function and tumor markers were performed for two years, with complications calculated. OS, DFS, local control rate, toxicity, hospital stay and expense were recorded. Results: The one and two-year OS rates were 96.08% and 92.16% versus 96.88% and 90.62% in the MWA and brachytherapy groups, respectively. The one and two-year DFS rates were 92.16% and 76.47% versus 93.75% and 78.13%, respectively. No significant differences were observed in log-rank analysis between the groups. Local control rates at six and 12 months were 100% and 96.08% versus 100% and 96.88%, while incidences of pleural effusion were 3.92% and 3.13%, respectively (P < 0.05). Medical cost was 3356.73 ± 206.87 and 6714.28 ± 35.43 U.S. dollars (P = 0.014). Conclusion: MWA and brachytherapy are effective and safe options for the treatment of NSCLC recurrence after first-line chemotherapy. Which modality should be considered is dependent upon tumor location, tumor size and experience of specialists. (© 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.) |
Databáze: | MEDLINE |
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