Common variant of CNTNAP2 gene modulate the social performances and functional connectivity of posterior right temporoparietal junction.

Autor: Bai T; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China., Zhang L; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China., Xie X; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China., Xiao G; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China., Huang W; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China., Li D; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China., Zu M; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China., Wei L; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China., Zuo X; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China., J I GJ; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei 238001, China., Hu P; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China., Zhu C; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China.; Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei 238001, China., Qiu B; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China.; Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China., Tian Y; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China., Wang K; Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Anhui Province, Hefei 230022, China.; Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei 238001, China.
Jazyk: angličtina
Zdroj: Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2019 Dec 30; Vol. 14 (12), pp. 1297-1305.
DOI: 10.1093/scan/nsaa008
Abstrakt: Social deficits are features of autism and highly heritable traits. A common variant in autism-related CNTNAP2 gene, rs2710102, has been linked with social performance, but the neural substrates are largely unknown. We investigated variations in social performance and functional connectivity (static and dynamic) in the subregions of right temporoparietal junction (RTPJ), a key node of brain social network, using resting-state magnetic resonance imaging (n = 399) by genotype at rs2710102 in healthy volunteers. Social performance was evaluated using the social domain of the Autism-Spectrum Quotient (AQ-social; n = 641) and fixation time on eye areas during an eye-tracking task (n = 32). According to previous evidence that the A-allele is the risk allele for social dysfunction, we classified participants into GG and A-allele carriers (AA/AG) groups. The A-allele carriers showed poor social performance (high AQ-social and short fixation time on eye areas) compared with the GG carriers. In the A-allele carriers, decreased stationary functional connectivity between the orbitofrontal cortex and posterior RTPJ (pRTPJ), and decreased dynamic functional connectivity (dFC) between the medial prefrontal cortex (mPFC) and pRTPJ were observed. The fixation time at eye areas positively were correlated with the pRTPJ-mPFC dFC. These findings provided insight for genetic effect on social behavior and its potential neural substrate.
(© The Author(s) 2020. Published by Oxford University Press.)
Databáze: MEDLINE
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