Targeting uptake transporters for cancer imaging and treatment.
| Autor: | Zhang Y; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA., Wang J; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Jan; Vol. 10 (1), pp. 79-90. Date of Electronic Publication: 2019 Dec 16. |
| DOI: | 10.1016/j.apsb.2019.12.005 |
| Abstrakt: | Cancer cells reprogram their gene expression to promote growth, survival, proliferation, and invasiveness. The unique expression of certain uptake transporters in cancers and their innate function to concentrate small molecular substrates in cells make them ideal targets for selective delivering imaging and therapeutic agents into cancer cells. In this review, we focus on several solute carrier (SLC) transporters known to be involved in transporting clinically used radiopharmaceutical agents into cancer cells, including the sodium/iodine symporter (NIS), norepinephrine transporter (NET), glucose transporter 1 (GLUT1), and monocarboxylate transporters (MCTs). The molecular and functional characteristics of these transporters are reviewed with special emphasis on their specific expressions in cancers and interaction with imaging or theranostic agents [ e.g ., I-123, I-131, 123 I-iobenguane (mIBG), 18 F-fluorodeoxyglucose ( 18 F-FDG) and 13 C pyruvate]. Current clinical applications and research areas of these transporters in cancer diagnosis and treatment are discussed. Finally, we offer our views on emerging opportunities and challenges in targeting transporters for cancer imaging and treatment. By analyzing the few clinically successful examples, we hope much interest can be garnered in cancer research towards uptake transporters and their potential applications in cancer diagnosis and treatment. (© 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.) |
| Databáze: | MEDLINE |
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