The Effect of Pregabalin on the Prevention of Succinylcholine-Induced Fasciculation and Myalgia.

Autor: Sane S; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran., Aghdashi MM; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran., Haki BK; Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran., Gholamveisi B; Department of Operating Room, Faculty of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran., Rajabzadeh M; Department of Medicine, Urmia University of Medical Science, Urmia, Iran., Golabi P; Department of Anesthesiology, Mahabad Imam Khomeini Hospital, Urmia University of Medical Science, Mahabad, Iran. Electronic address: behzad_emt@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses [J Perianesth Nurs] 2020 Jun; Vol. 35 (3), pp. 255-259. Date of Electronic Publication: 2020 Jan 25.
DOI: 10.1016/j.jopan.2019.11.005
Abstrakt: Purpose: This study evaluates the effect of pregabalin on fasciculation and myalgia after using succinylcholine.
Design: This randomized double-blind prospective study was conducted among 100 patients aged 20 to 60 years old.
Methods: Pregabalin (300 mg) and placebo (in capsule form) were placed in similar containers. The results were analyzed by SPSS 23 software, and statistical analysis consisted of χ 2 test and t test, and a P value less than .05 was considered significant.
Findings: The mean pain score in the group receiving pregabalin was lower than the placebo group. According to the χ 2 test, there was a significant difference between the two groups in the frequency of fasciculation (P = .003). Mean fasciculation severity in the pregabalin group was lower than placebo group. According to t test, there was a significant difference in the mean fasciculation severity between the two groups (P = .002).
Conclusions: This study showed that 300 mg of pregabalin was effective in reducing postoperative fasciculation and myalgia in patients treated with succinylcholine.
(Copyright © 2019 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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