Imprinting of the immune system by the microbiota early in life.

Autor: Al Nabhani Z; Microenvironment and Immunity Unit, Institut Pasteur, INSERM U1224, Paris, France., Eberl G; Microenvironment and Immunity Unit, Institut Pasteur, INSERM U1224, Paris, France. gerard.eberl@pasteur.fr.
Jazyk: angličtina
Zdroj: Mucosal immunology [Mucosal Immunol] 2020 Mar; Vol. 13 (2), pp. 183-189. Date of Electronic Publication: 2020 Jan 27.
DOI: 10.1038/s41385-020-0257-y
Abstrakt: The ontogeny and maturation of the immune system is modulated by the microbiota. During fetal life, the mother's microbiota produces compounds that are transferred to the fetus and offspring, and enhance the generation of innate immune cells. After birth, the colonizing microbiota induces the development of intestinal lymphoid tissues and maturation of myeloid and lymphoid cells, and imprints the immune system with a reactivity level that persists long after weaning into adulthood. When the cross-talk between host and microbiota is perturbed early in life, a pathological imprinting may develop that is characterized by excessive immune reactivity in adulthood, which translates into increased susceptibility to inflammatory pathologies. In this review, we discuss the recent data that demonstrate the existence of a time window of opportunity early in life during which mice and human have to be exposed to microbiota in order to develop a balanced immune system. We also discuss the factors involved in imprinting, such as the microbiota, immune cells and stromal cells, as well as the nature of imprinting.
Databáze: MEDLINE
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