The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data.

Autor: Henning SW; Oncology Research Institute, Loyola University Chicago, Maywood, Illinois, United States of America., Jaishankar D; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America., Barse LW; Oncology Research Institute, Loyola University Chicago, Maywood, Illinois, United States of America., Dellacecca ER; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America., Lancki N; Department of Preventive Medicine, Northwestern University, Chicago, Illinois, United States of America., Webb K; Division of Dermatology, Loyola University Chicago, Maywood, Illinois, United States of America., Janusek L; Marcella Niehoff School of Nursing, Loyola University Chicago, Maywood, Illinois, United States of America., Mathews HL; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, United States of America., Price RN Jr; Office of Informatics and System Development, Loyola University Chicago, Maywood, Illinois, United States of America., Le Poole IC; Department of Preventive Medicine, Northwestern University, Chicago, Illinois, United States of America.; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Jan 27; Vol. 15 (1), pp. e0227909. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0227909
Abstrakt: Vitiligo is a T-cell mediated skin disorder characterized by progressive loss of skin color. In individuals genetically predisposed to the disease, various triggers contribute to the initiation of vitiligo. Precipitating factors can stress the skin, leading to T-cell activation and recruitment. Though hereditary factors are implicated in the pathogenesis of vitiligo, it is unknown whether precipitating, stressful events play a role in vitiligo. To understand this, we utilized a validated perceived stress scale (PSS) to measure this parameter in vitiligo patients compared to persons without vitiligo. Additionally, we probed a clinical database, using a knowledge linking software called ROCKET, to gauge stress-related conditions in the vitiligo patient population. From a pool of patients in an existing database, a hundred individuals with vitiligo and twenty-five age- and sex-matched comparison group of individuals without vitiligo completed an online survey to quantify their levels of perceived stress. In parallel, patients described specifics of their disease condition, including the affected body sites, the extent, duration and activity of their vitiligo. Perceived stress was significantly higher among vitiligo individuals compared to those without vitiligo. ROCKET analyses suggested signs of metabolic-related disease (i.e., 'stress') preceding vitiligo development. No correlation was found between perceived stress and the stage or the extent of disease, suggesting that elevated stress may not be a consequence of pigment loss alone. The data provide further support for stress as a precipitating factor in vitiligo development.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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