Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study.

Autor: Ciapponi A; Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina., Virgilio SA; Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina., Berrueta M; Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina., Soto NC; Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina., Ciganda Á; Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina., Rojas Illanes MF; Hospital Dr. Bernardo Sepúlveda, Mexico DF, Mexico., Rubio Martinez B; Hospital Dr. Bernardo Sepúlveda, Mexico DF, Mexico., Gamba J; Fundación Universitaria Sánitas, Bogotá, Colombia., González Salazar CA; Fundación Universitaria Sánitas, Bogotá, Colombia., Rocha Rodríguez JN; Fundación Universitaria Sánitas, Bogotá, Colombia., Scarpellini B; Janssen-Cilag Farmacêutica Ltda, São Paulo, Brazil., Bravo Perdomo AM; Janssen-Cilag Farmacêutica Ltda, Bogotá, Colombia., Machnicki G; Janssen-Cilag Farmacêutica Ltda, Buenos Aires, Argentina., Aldunate L; Janssen-Cilag Farmacêutica Ltda, Buenos Aires, Argentina., De Paula J; Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina., Bardach A; Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Jan 27; Vol. 15 (1), pp. e0228256. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0228256
Abstrakt: Background and Aims: Ulcerative Colitis (UC) and Crohn's Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia.
Methods: We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia.
Results: The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia. The UC/CD prevalence ratio in Mexico and Colombia was 1.50:1 and 4.5:1 respectively. In Mexico, the female/male prevalence ratio for UC was 1.50:1 and 1.28:1 for CD, while in Colombia this ratio was 0.68:1 for UC and 0.8:1 for CD. In Mexico the relapse rate for UC was 63.3% and 72.5% for CD, while those rates in Colombia were 58.2% for UC and 58.3% for CD.
Conclusions: The estimated burden of disease of IBD in Mexico and Colombia is not negligible. Although these findings need to be confirmed by population-based studies, they are useful for decision-makers, practitioners and patients with this condition.
Competing Interests: This work was funded by Janssen-Cilag Pharmaceutical. This does not alter our adherence to PLOS ONE policies on sharing data and materials. In the synthesis of the main results of the study as well as in the development of the writing of the manuscript did not interfere any interest. In addition to this, the present study is of the epidemiological type, where the main results are related to the estimation of prevalence and incidence of the disease, so we consider that it is still difficult for them to be influenced by interests outside those of the main researchers. There are no patents, products in development or marketed products evaluated in this research to declare.
Databáze: MEDLINE
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