[Cutaneous hyperpigmentation secondary to vitamin B12 deficiency in an infant].

Autor:	Viada Pelaez MC; Servicio de Dermatología, Hospital Nacional de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad de Buenos Aires, Argentina. candeviada@hotmail.com., Buján MM; Servicio de Dermatología, Hospital Nacional de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad de Buenos Aires, Argentina., Cervini AB; Servicio de Dermatología, Hospital Nacional de Pediatría 'Prof. Dr. Juan P. Garrahan', Ciudad de Buenos Aires, Argentina.
Jazyk:	Spanish; Castilian
Zdroj:	Archivos argentinos de pediatria [Arch Argent Pediatr] 2020 Feb; Vol. 118 (1), pp. e63-e66.
DOI:	10.5546/aap.2020.e63
Abstrakt:	Cutaneous hyperpigmentation is a rare clinical feature of vitamin B12 (cobalamin) deficiency. The cause is unknown and there are different hypothesis about the pathogenesis of the hyperpigmentation. We report the case of an 8-month-old girl, with history of neuromadurative delay, hypotonia, anemia and neutropenia, who was referred to our Service by brownish hyperpigmentation on her hands and feet of 3 months of evolution. Based on the clinical suspicion of vitamin B12 deficiency, we performed a laboratory dosage that showed decreased levels of cobalamin, reason for which replacement therapy was indicated. It highlights the importance of the presumption of vitamin B12 deficiency as a cause of cutaneous hyperpigmentation and its rapid resolution after the establishment of the appropriate treatment. Competing Interests: The authors report no conflicts of interest in this work. (Sociedad Argentina de Pediatría.)
Databáze:	MEDLINE
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