Slowed Luminance Reaction Times in Cervical Dystonia: Disordered Superior Colliculus Processing.

Autor: Williams L; Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland., Butler JS; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland.; School of Mathematical Sciences, Technological University Dublin, Dublin, 2, Dublin, Ireland., Thirkettle M; Department of Psychology, Sociology & Politics, Sheffield Hallam University, Sheffield, United Kingdom., Stafford T; Department of Psychology, University of Sheffield, Sheffield, United Kingdom., Quinlivan B; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland., McGovern E; Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland., O'Riordan S; Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland., Redgrave P; Department of Psychology, University of Sheffield, Sheffield, United Kingdom., Reilly R; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland., Hutchinson M; Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2020 May; Vol. 35 (5), pp. 877-880. Date of Electronic Publication: 2020 Jan 26.
DOI: 10.1002/mds.27975
Abstrakt: Background: Abnormal temporal discrimination in cervical dystonia is hypothesized to be attributable to disrupted processing in the superior colliculus. The fast, luminance-based, retinotectal pathway, projects to the superior colliculus; chromatic stimuli responses, by the retino-geniculo-calcarine pathway, are up to 30 ms longer.
Objectives: We sought to interrogate visual processing and reaction times in patients with cervical dystonia compared with healthy controls. We hypothesized that cervical dystonia patients would have impaired reaction times to luminance based stimuli accessing the retino-tectal pathway in comparison to healthy control participants.
Methods: In 20 cervical dystonia and 20 age-matched control participants, we compared reaction times to two flashing visual stimuli: (1) a chromatic annulus and (2) a luminant, noncolored annulus. Participants pressed a joystick control when they perceived the annulus flashing.
Results: Reaction times in control participants were 20 ms significantly faster in the luminant condition than the chromatic (P = 0.017). Patients with cervical dystonia had no reaction time advantage in response to the luminant stimulus.
Conclusion: Cervical dystonia patients (compared to control participants) demonstrated no reduction in their reaction time to luminant stimuli, processed through the retinotectal pathway. This finding is consistent with superior colliculus dysfunction in cervical dystonia. © 2020 International Parkinson and Movement Disorder Society.
(© 2020 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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