Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish.

Autor: Xu S; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Xie F; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Tian L; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Fallah S; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Babaei F; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Manno SHC; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Manno FAM; School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, New South Wales, Australia., Zhu L; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Wong KF; Department of Biomedical Engineering, Polytechnic University of Hong Kong, Hong Kong SAR, People's Republic of China., Liang Y; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Ramalingam R; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Sun L; Department of Biomedical Engineering, Polytechnic University of Hong Kong, Hong Kong SAR, People's Republic of China., Wang X; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Plumb R; Waters Technologies Corporation, Milford, Massachusetts, USA., Gethings L; Waters Technologies Corporation, Milford, Massachusetts, USA., Lam YW; Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People's Republic of China., Cheng SH; Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People's Republic of China.; State Key Laboratory of Marine Pollution (SKLMP) at City University of Hong Kong, Hong Kong SAR, People's Republic of China.; Department of Materials Science and Engineering, College of Science and Engineering, City University of Hong Kong, Hong Kong SAR, People's Republic of China.
Jazyk: angličtina
Zdroj: The Journal of endocrinology [J Endocrinol] 2020 Apr; Vol. 245 (1), pp. 39-51.
DOI: 10.1530/JOE-19-0413
Abstrakt: Sexual differences have been observed in the onset and prognosis of human cardiovascular diseases, but the underlying mechanisms are not clear. Here, we found that zebrafish heart regeneration is faster in females, can be accelerated by estrogen and is suppressed by the estrogen-antagonist tamoxifen. Injuries to the zebrafish heart, but not other tissues, increased plasma estrogen levels and the expression of estrogen receptors, especially esr2a. The resulting endocrine disruption induces the expression of the female-specific protein vitellogenin in male zebrafish. Transcriptomic analyses suggested heart injuries triggered pronounced immune and inflammatory responses in females. These responses, previously shown to elicit heart regeneration, could be enhanced by estrogen treatment in males and reduced by tamoxifen in females. Furthermore, a prior exposure to estrogen preconditioned the zebrafish heart for an accelerated regeneration. Altogether, this study reveals that heart regeneration is modulated by an estrogen-inducible inflammatory response to cardiac injury. These findings elucidate a previously unknown layer of control in zebrafish heart regeneration and provide a new model system for the study of sexual differences in human cardiac repair.
Databáze: MEDLINE