Comparative effectiveness of radical cystectomy and radiotherapy without chemotherapy in frail patients with bladder cancer.

Autor: D'Andrea D; Department of Urology, Medical University of Vienna, Vienna, Austria., Soria F; Department of Urology, Medical University of Vienna, Vienna, Austria.; Division of Urology, Department of Surgical Sciences, University of Studies of Torino, Turin, Italy., Zehetmayer S; Center for Medical Statistics, Informatics, and Intelligent Systems, Section for Medical Statistics, Medical University of Vienna, Vienna, Austria., Stangl-Kremser J; Department of Urology, Medical University of Vienna, Vienna, Austria., Grubmüller B; Department of Urology, Medical University of Vienna, Vienna, Austria., Abufaraj M; Department of Urology, Medical University of Vienna, Vienna, Austria.; Division of Urology, Department of Special Surgery, Jordan University Hospital, The 2 University of Jordan, Amman, Jordan., Gust K; Department of Urology, Medical University of Vienna, Vienna, Austria., Kimura S; Department of Urology, Medical University of Vienna, Vienna, Austria., Babjuk M; Department of Urology, Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic., Goldner GM; Department of Radiotherapy, Medical University of Vienna, Vienna, Austria., Shariat SF; Department of Urology, Medical University of Vienna, Vienna, Austria.; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Urology, Weill Cornell Medical College, New York, NY, USA.; Department of Urology, Second Faculty of Medicine, Charles University, Prag, Czech Republic.; Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Scandinavian journal of urology [Scand J Urol] 2020 Feb; Vol. 54 (1), pp. 52-57. Date of Electronic Publication: 2020 Jan 24.
DOI: 10.1080/21681805.2019.1711160
Abstrakt: Objectives: To evaluate cancer-specific (CSS) and overall survival (OS) in a group of frail patients who were treated with RT without chemotherapy and to compare them with a matched cohort of patients treated with RC. Methods: This study identified 71 patients treated with RT only for high-risk bladder cancer. Patients with metastatic (cN + or cM+) or non-resectable tumors (cT4) and those who received any form of chemotherapy were excluded. Patients where matched 1:1 using propensity scores which adjusted for the effects of age, clinical stage and age-adjusted Charlson comorbidity index (CCI). OS and CSS were evaluated using the Cox proportional hazards regression model and the Fine and Gray competing risk model. Results: In the overall population, RT was associated with worse OS (HR = 1.78, 95% CI = 1.15-2.77, p  = 0.01) compared to RC, but not with CSS (HR 1.1, p  = 0.74). In the matched cohort, RT was neither associated with OS nor CSS ( p  > 0.05) compared to RC. In the competing risk analyses no statistically significant association of any of the treatments was observed in the total or in the matched data set ( p  > 0.05). Conclusion: The use of RT may be an alternative option in well selected patients with limited disease who are considered unfit for systemic chemotherapy and RC. Future research should focus on improving patient selection and assess the quality-of-life as well as the need for reintervention in patients treated with RT.
Databáze: MEDLINE
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