The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme.

Autor: Gayer-Anderson C; Department of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, England., Jongsma HE; PsyLife Group, Division of Psychiatry, University College London, London, England.; Department of Psychiatry, University of Cambridge, Cambridge, England., Di Forti M; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England., Quattrone D; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England., Velthorst E; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, USA.; Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., de Haan L; Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., Selten JP; Institute for Mental Health, GGZ Rivierduinen, Leiden, The Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands., Szöke A; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 15 Neuro-Psychiatrie Translationnelle, Créteil, France.; AP-HP, Pôle de Psychiatrie des Hôpitaux Universitaires Henri Mondor, Créteil, France.; Fondation FondaMental, Créteil, France., Llorca PM; EA 7280 Npsydo, Université Clermont Auvergne, Clermont-Ferrand, France., Tortelli A; Establissement Public de Santé, Maison Blanche, Paris, France., Arango C; Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, ISGM, CIBERSAM, Madrid, Spain., Bobes J; Department of Medicine, Psychiatry Area, School of Medicine, Universidad de Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, Oviedo, Spain., Bernardo M; Barcelona Clinic Schizophrenia Unit, Hospital Clinic, Department of Medicine, Neuroscience Institute, University of Barcelona, Institut d'Investigacions Biomèdiques, August Pi I Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain., Sanjuán J; Department of Psychiatry, School of Medicine, Universidad de Valencia, Centro de Investigación Biomédica en Red de Salud Mental, Valencia, Spain., Santos JL; Department of Psychiatry, Hospital 'Virgen de la Luz', Cuenca, Spain., Arrojo M; Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain., Parellada M; Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, ISGM, CIBERSAM, Madrid, Spain., Tarricone I; Department of Biomedical and NeuroMotor Sciences, Psychiatry Unit, Alma Mater Studiorium Università di Bologna, Bologna, Italy., Berardi D; Department of Biomedical and NeuroMotor Sciences, Psychiatry Unit, Alma Mater Studiorium Università di Bologna, Bologna, Italy., Ruggeri M; Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy., Lasalvia A; Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.; Section of Psychiatry, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy., Ferraro L; Department of Experimental Biomedicine and Clinical Neuroscience, Section of Psychiatry, University of Palermo, Palermo, Italy., La Cascia C; Department of Experimental Biomedicine and Clinical Neuroscience, Section of Psychiatry, University of Palermo, Palermo, Italy., La Barbera D; Department of Experimental Biomedicine and Clinical Neuroscience, Section of Psychiatry, University of Palermo, Palermo, Italy., Menezes PR; Department of Preventive Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Del-Ben CM; Division of Psychiatry, Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, Universidade de São Paulo, São Paulo, Brazil., Rutten BP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands., van Os J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.; Department of Psychiatry, Brain Center Rudolf Magnus, Utrecht University Medical Centre, Utrecht, The Netherlands.; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England., Jones PB; Department of Psychiatry, University of Cambridge, Cambridge, England.; CAMEO Early Intervention Service, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, England., Murray RM; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England., Kirkbride JB; PsyLife Group, Division of Psychiatry, University College London, London, England., Morgan C; Department of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, England. craig.morgan@kcl.ac.uk.
Jazyk: angličtina
Zdroj: Social psychiatry and psychiatric epidemiology [Soc Psychiatry Psychiatr Epidemiol] 2020 May; Vol. 55 (5), pp. 645-657. Date of Electronic Publication: 2020 Jan 23.
DOI: 10.1007/s00127-020-01831-x
Abstrakt: Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders.
Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort.
Conclusions: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.
Databáze: MEDLINE
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