Neutrophilia is associated with a poorer clinical outcome in dogs with chronic hepatitis.

Autor: Breheny CR; Hospital for Small Animals, University of Edinburgh Royal Dick School of Veterinary Studies, Easter Bush, UK cbreheny@exseed.ed.ac.uk., Handel I; Centre for Infectious Diseases, University of Edinburgh, Edinburgh, UK., Banner S; Gordons Vets, Musselburgh, UK., Milne EM; Veterinary Pathology Unit, University of Edinburgh, Edinburgh, UK., Morrison LR; Veterinary Pathology Unit, University of Edinburgh, Edinburgh, UK., Smith SH; Veterinary Pathology Unit, University of Edinburgh, Edinburgh, UK., Kilpatrick S; Hospital for Small Animals, University of Edinburgh Royal Dick School of Veterinary Studies, Easter Bush, UK., Gow A; Hospital for Small Animals, University of Edinburgh Royal Dick School of Veterinary Studies, Easter Bush, UK., Mellanby RJ; Hospital for Small Animals, University of Edinburgh Royal Dick School of Veterinary Studies, Easter Bush, UK.
Jazyk: angličtina
Zdroj: The Veterinary record [Vet Rec] 2020 Sep 19; Vol. 187 (6), pp. 234. Date of Electronic Publication: 2020 Jan 23.
DOI: 10.1136/vr.105533
Abstrakt: Background: Liver disease is a common cause of morbidity and mortality in dogs. Currently, it is challenging to prognosticate in these cases. The aim of this study was to evaluate the utility of the haematological variables in dogs with chronic hepatitis.
Methods: Dogs with chronic hepatitis confirmed on histopathology had presenting haematological values retrospectively obtained and evaluated against survival time. Eighty-two dogs met the inclusion criteria and their data analysed.
Results: Neutrophilic patients, with a count greater than 12×10 9 /l, controlled for sex and age, had a shorter survival time (P≤0.01). In dogs, neutrophilia at presentation predicted a poor outcome, whereas the other haematological parameters were not prognostically informative. When the dogs were split into even quarters on the basis of their neutrophil count, those within the higher quartiles had poorer survival times. Neutrophilia was associated with a poorer survival time in comparison to those patients with a lower count.
Conclusion: The relationship between neutrophils, inflammation and clinical outcome is deserving of future study in dogs with chronic hepatitis.
Competing Interests: Competing interests: None declared.
(© British Veterinary Association 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze: MEDLINE
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