Fabrication of smart stimuli-responsive mesoporous organosilica nano-vehicles for targeted pesticide delivery.

Autor: Liang Y; College of Plant Protection, China Agricultural University, Beijing, China., Gao Y; College of Plant Protection, China Agricultural University, Beijing, China., Wang W; College of Plant Protection, China Agricultural University, Beijing, China., Dong H; College of Plant Protection, China Agricultural University, Beijing, China., Tang R; College of Plant Protection, China Agricultural University, Beijing, China., Yang J; College of Plant Protection, China Agricultural University, Beijing, China., Niu J; College of Plant Protection, China Agricultural University, Beijing, China., Zhou Z; College of Plant Protection, China Agricultural University, Beijing, China., Jiang N; College of Plant Protection, China Agricultural University, Beijing, China., Cao Y; College of Plant Protection, China Agricultural University, Beijing, China. Electronic address: caoysong@126.com.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2020 May 05; Vol. 389, pp. 122075. Date of Electronic Publication: 2020 Jan 15.
DOI: 10.1016/j.jhazmat.2020.122075
Abstrakt: It is highly desirable to construct stimuli-responsive nanocarriers for improving pesticides targeting and preventing the pesticides premature release. In this work, a novel redox and α-amylase dual stimuli-responsive pesticide delivery system was established by bonding functionalized starch with biodegradable disulfide-bond-bridged mesoporous silica nanoparticles which loaded with avermectin (avermectin@MSNs-ss-starch nanoparticles). The results demonstrated that the loading capacity of avermectin@MSNs-ss-starch nanoparticles for avermectin was approximately 9.3 %. The starch attached covalently on the mesoporous silica nanoparticles could protect avermectin from photodegradation and prevent premature release of active ingredient. Meanwhile, the coated starch and disulfide-bridged structure of nanoparticles could be decomposed and consequently release of the avermectin on demand when nanoparticles were metabolized by glutathione and α-amylase in insects. The bioactivity survey confirmed that avermectin@MSNs-ss-starch nanoparticles had a longer duration in controlling Plutella xylostella larvae compared to avermectin emulsifiable concentrate. In consideration of the superior insecticidal activity and free of toxic organic solvent, this target-specific pesticide release system has promising potential in pest management.
Competing Interests: Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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