Evaluation of lower urinary tract symptoms in children with Down syndrome: A prospective, case-controlled cohort study.

Autor: Kızılay F; Department of Urology, Ege University Hospital, Izmir, Turkey., İrer B; Department of Urology, Izmir Metropolitan Municipality Esrefpasa Hospital, Izmir, Turkey., Özalp Kızılay D; Department of Pediatric Endocrinology, Cigli Regional Training Hospital, Izmir, Turkey., Şimşir A; Department of Urology, Ege University Hospital, Izmir, Turkey., Kalemci S; Department of Urology, Ege University Hospital, Izmir, Turkey., Şen V; Department of Urology, Manisa State Hospital, Manisa, Turkey., Altay B; Department of Urology, Ege University Hospital, Izmir, Turkey., Çoğulu Ö; Department of Medical Genetics, Ege University Hospital, Izmir, Turkey.
Jazyk: angličtina
Zdroj: Neurourology and urodynamics [Neurourol Urodyn] 2020 Feb; Vol. 39 (2), pp. 833-840. Date of Electronic Publication: 2020 Jan 23.
DOI: 10.1002/nau.24293
Abstrakt: Aims: In children with Down syndrome (DS) which causes cognitive impairment and intellectual disability (ID), dysfunctional voiding is proposed to be more common than in the normal population. In this study, we aimed to compare the voiding symptoms of DS children with a control group by validated questionnaires.
Methods: Thirty-seven DS children without any previous urological complaints and 59 non-DS healthy children as control group was included in the study. Overactive bladder symptoms and dysfunctional voiding were evaluated with validated Overactive Bladder Questionnaire (OAB-V8) and Dysfunctional Voiding Symptom Score (DVSS) questionnaire, respectively. Data were arranged, descriptive and comparative statistical analysis were performed.
Results: Demographic data of the two groups were similar except age of completing toilet training being higher in DS group. Total OAB-V8 and DVSS scores were significantly higher in the DS group. The mean scores of questions regarding voiding frequency, urgency and urgency incontinence in OAB-V8 were significantly higher in the DS group. The mean daytime incontinence, urgency, urgency incontinence, and quality of life scores in the DVSS were also significantly higher in the DS group.
Conclusions: DS children have more frequent dysfunctional voiding than the normal population. ID of these children may prevent the expression of these symptoms. Awareness and early detection of these symptoms are crucial to prevent devastating complications such as renal failure. Therefore, validated questionnaires are simple, useful, and noninvasive methods.
(© 2020 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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