The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis.

Autor: Semenova EA; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.; Department of Biochemistry, Kazan Federal University, Kazan, Russia., Miyamoto-Mikami E; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Akimov EB; Central Cross Country Ski Association, Madison, WI, USA., Al-Khelaifi F; Anti Doping Laboratory Qatar, Sports City, Doha, Qatar.; UCL-Medical School, Royal Free Campus, London, UK., Murakami H; Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, NIBIOHN, Tokyo, Japan., Zempo H; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.; Faculty of Health and Nutrition, Tokyo Seiei College, Tokyo, Japan., Kostryukova ES; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia., Kulemin NA; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia., Larin AK; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia., Borisov OV; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.; Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany., Miyachi M; Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, NIBIOHN, Tokyo, Japan., Popov DV; Laboratory of Exercise Physiology, Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia., Boulygina EA; Omics Technologies OpenLab, Kazan Federal University, Kazan, Russia., Takaragawa M; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Kumagai H; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.; Research Fellow of Japanese Society for the Promotion of Science, Tokyo, Japan., Naito H; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Pushkarev VP; Medical Genetic Centre 'Progen', Moscow, Russia.; Moscow Center of Advanced Sport Technologies, Moscow, Russia.; Department of the Theory of Physical Culture and Biomechanics, Ural State University of Physical Culture, Chelyabinsk, Russia., Dyatlov DA; Department of the Theory of Physical Culture and Biomechanics, Ural State University of Physical Culture, Chelyabinsk, Russia., Lekontsev EV; Methodical and Analytical Department, Regional Center for Sports Training, Chelyabinsk, Russia.; Research Institute of Olympic Sports, Ural State University of Physical Culture, Chelyabinsk, Russia., Pushkareva YE; Department of Pediatrics, South Ural State Medical University, Chelyabinsk, Russia., Andryushchenko LB; Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia., Elrayess MA; Biomedical Research Center, Qatar University, Doha, Qatar., Generozov EV; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia., Fuku N; Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan., Ahmetov II; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia. i.akhmetov@ljmu.ac.uk.; Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia. i.akhmetov@ljmu.ac.uk.; Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia. i.akhmetov@ljmu.ac.uk.; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Byrom St, Liverpool, L3 5AF, UK. i.akhmetov@ljmu.ac.uk.
Jazyk: angličtina
Zdroj: European journal of applied physiology [Eur J Appl Physiol] 2020 Mar; Vol. 120 (3), pp. 665-673. Date of Electronic Publication: 2020 Jan 22.
DOI: 10.1007/s00421-020-04306-8
Abstrakt: Purpose: Iron is an important component of the oxygen-binding proteins and may be critical to optimal athletic performance. Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino acid replacement, in the HFE is associated with elevated iron indexes and may give some advantage in endurance-oriented sports. The aim of the present study was to investigate the association between the HFE H63D polymorphism and elite endurance athlete status in Japanese and Russian populations, aerobic capacity and to perform a meta-analysis using current findings and three previous studies.
Methods: The study involved 315 international-level endurance athletes (255 Russian and 60 Japanese) and 809 healthy controls (405 Russian and 404 Japanese). Genotyping was performed using micro-array analysis or by PCR. VO 2max in 46 male Russian endurance athletes was determined using gas analysis system.
Results: The frequency of the iron-increasing CG/GG genotypes was significantly higher in Russian (38.0 vs 24.9%; OR 1.85, P = 0.0003) and Japanese (13.3 vs 5.0%; OR 2.95, P = 0.011) endurance athletes compared to ethnically matched controls. The meta-analysis using five cohorts (two French, Japanese, Spanish, and Russian; 586 athletes and 1416 controls) showed significant prevalence of the CG/GG genotypes in endurance athletes compared to controls (OR 1.96, 95% CI 1.58-2.45; P = 1.7 × 10 -9 ). Furthermore, the HFE G allele was associated with high V̇O 2max in male athletes [CC: 61.8 (6.1), CG/GG: 66.3 (7.8) ml/min/kg; P = 0.036].
Conclusions: We have shown that the HFE H63D polymorphism is strongly associated with elite endurance athlete status, regardless ethnicities and aerobic capacity in Russian athletes.
Databáze: MEDLINE
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