Anticancer and Antibacterial Activities of Silver Nanoparticles (AgNPs) Synthesized from Cucumis melo L.

Autor:	Wang Y; Extrathoracic and Thyroid Mammary Surgery, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130021, China., Zhang X; Encephalopathy Center, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130021, China., Bai Y; Extrathoracic and Thyroid Mammary Surgery, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130021, China., Li W; Second Department of Surgery, Harbin Fifth Hospital, Harbin, 150040, China., Li X; General Surgery, Ewenki Banner People's Hospital, Hulunbeir, 021100, China., Xing X; Physical Examination Center, China-Japan Union Hospital of Jilin University, Changchun, 130000, China., Wang C; Respiratory Department, First Clinical College, Academy of Traditional Chinese Medicine, Changchun, 130021, China., Gao L; Brain Surgery, Liaoyuan Hospital of Traditional Chinese Medicine, Liaoyuan, 136000, China., Yogi M; Department of Biotechnology/Microbiology, East West First Grade College of Science, Bengaluru 560091, India., Swamy MK; Department of Biotechnology/Microbiology, East West First Grade College of Science, Bengaluru 560091, India., Dupadahalli K; Department of Biotechnology/Microbiology, East West First Grade College of Science, Bengaluru 560091, India., Rudramurthy GR; Department of Biotechnology/Microbiology, East West First Grade College of Science, Bengaluru 560091, India., Purushotham B; Department of Biotechnology/Microbiology, East West First Grade College of Science, Bengaluru 560091, India., Rohit KC; Department of Biotechnology/Microbiology, East West First Grade College of Science, Bengaluru 560091, India., Fu J; Reproductive Center, Jilin Provincial People's Hospital, Changchun, 130021, China.
Jazyk:	angličtina
Zdroj:	Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2020 Jul 01; Vol. 20 (7), pp. 4143-4151.
DOI:	10.1166/jnn.2020.17524
Abstrakt:	The current investigation reports the structural and biological evaluation of silver nanoparticles (AgNPs) biosynthesized from the pericarp extract of Cucumis melo L. (muskmelon). The AgNPs were characterized by ultraviolet-visible (UV-Vis) spectrophotometry, XRD (X-ray diffraction), SEM (scanning electron microscopy) and EDAX (energy-dispersive X-ray spectroscopy). The XRD analysis showed that biosynthesized AgNPs were having FCC (face centered cubic) crystalline structures. Further, the SEM and EDAX showed spherically shaped AgNPs having an average size of 25 nm. The AgNPs effectively inhibited the growth of Bacillus subtilis and Escherichia coli . Moreover, the cytotoxic assay of AgNPs revealed effective cytotoxicity against different cancer cells, such as HeLa, HCT-116, PC-3 and Jurkat in a dose reliant way. The cell viability was noticed to range from 50% to 60% with IC 50 values ranging from 150 μ g/mL to 224 μ g/mL. The lower cell viability indicates the toxic effects of biosynthesized AgNPs against these malignant cells. Thus, the current study shows that these biosynthesized AgNPs could be utilized in various medical applications in near future.
Databáze:	MEDLINE
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