| Autor: |
Mai NT; University of Transport and Communications, Hanoi, Viet Nam., Dung DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam., Nga TT; University of Transport and Communications, Hanoi, Viet Nam., Xuan VT; University of Transport and Communications, Hanoi, Viet Nam., Doan VV; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam., Tai BH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam.; Graduate University of Science and Technology, VAST, Hanoi, Viet Nam., Nhiem NX; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam.; Graduate University of Science and Technology, VAST, Hanoi, Viet Nam., Yen PH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam., Kiem PV; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam.; Graduate University of Science and Technology, VAST, Hanoi, Viet Nam., Seo Y; College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea., Namkung W; College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea., Park S; Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon, Republic of Korea., Kim SH; College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea. |
| Abstrakt: |
Ten triterpenoid glycosides including two undescribed compounds ( 1 and 2 ) were isolated from the methanol extract of Allium ascalonicum rhizomes. These compounds were structurally elucidated to be 3 β - O - α -L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-19 α -hydroxyolean-12-ene-28-oic acid 28- O -[α-L-rhamnopyranosyl-(1→2)- β -D-glucopyranosyl] ester ( 1 ), 3- O - β -D-glucopyranosyl-(1→3)-[ α- L-rhamnopyranosyl-(1→2)]- α- L-arabinopyranosyl-3 β ,19 α -dihydroxyoleanane-12-en-28-oic acid ( 2 ), lactifoloside C ( 3 ), lactifoloside H ( 4 ), randiasaponin IV ( 5 ), kudinoside G ( 6 ), ilexkudinoside W ( 7 ), lactifoloside G ( 8 ), kudinoside D ( 9 ), and ilexkudinoside T ( 10 ) by analyzing their HR-ESI-MS, NMR spectral data and by comparison with those reported in the literature. Compounds 1 - 10 were evaluated for anoctamin-1 (ANO1) inhibitory activity using yellow fluorescent protein reduction assays. At the concentration of 30 µM, compounds 2 and 9 displayed moderate ANO1 inhibitory percentages of 28.9 ± 0.85% and 26.2 ± 0.65%, respectively. |
