Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20.

Autor: Midgley SE; Department for Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark., Benschop K; Centre for Infectious Disease Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands., Dyrdak R; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Mirand A; CHU Clermont-Ferrand, Centre National de Référence des entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France.; Université Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France., Bailly JL; Université Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement, Clermont-Ferrand, France., Bierbaum S; Institute of Virology, University of Freiburg, Freiburg, Germany., Buderus S; Department of General Pediatrics, St.-Marien-Hospital, Bonn, Germany., Böttcher S; National Reference Center for Poliomyelitis and Enteroviruses, Robert Koch-Institute, Berlin, Germany., Eis-Hübinger AM; Institute of Virology, University of Bonn Medical Center, Bonn, Germany., Hönemann M; Institute of Virology, University of Leipzig, Leipzig, Germany., Jensen VV; Department for Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark., Hartling UB; Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark., Henquell C; CHU Clermont-Ferrand, Centre National de Référence des entérovirus et parechovirus - Laboratoire Associé, Laboratoire de Virologie, Clermont-Ferrand, France., Panning M; Institute of Virology, University of Freiburg, Freiburg, Germany., Thomsen MK; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark., Hodcroft EB; Biozentrum, University of Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics, Basel, Switzerland., Meijer A; Centre for Infectious Disease Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Jazyk: angličtina
Zdroj: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2020 Jan; Vol. 25 (2).
DOI: 10.2807/1560-7917.ES.2020.25.2.1900749
Abstrakt: Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.
Databáze: MEDLINE