Evaluating a pragmatic estimate of insulin sensitivity in Latino youth with obesity.

Autor: Peña A; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona.; College of Health Solutions, Arizona State University, Phoenix, Arizona., Olson ML; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona.; Department of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, Arizona., Soltero EG; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona.; Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona., Lee C; College of Health Solutions, Arizona State University, Phoenix, Arizona., Toledo MJ; College of Health Solutions, Arizona State University, Phoenix, Arizona., Ayers SL; Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona., Shaibi GQ; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona.; College of Health Solutions, Arizona State University, Phoenix, Arizona.; Department of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, Arizona.; Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona.
Jazyk: angličtina
Zdroj: Clinical obesity [Clin Obes] 2020 Apr; Vol. 10 (2), pp. e12353. Date of Electronic Publication: 2020 Jan 21.
DOI: 10.1111/cob.12353
Abstrakt: The whole-body insulin sensitivity index (WBISI) is a widely used surrogate of insulin sensitivity estimated from glucose and insulin concentrations during an oral glucose tolerance test (OGTT). The original WBISI uses five timepoints but reduced sampling models have been proposed. These reduced models have not been applied to the paediatric population. The purpose of this study is to compare cross-sectional agreement and changes in response to lifestyle intervention between the original WBISI and the WBISI 120 using fasting and 2-hour glucose and insulin concentrations from OGTT among Latino adolescents with obesity. We also examined the cost-differential between the two measures. Secondary analyses were conducted with data from Latino adolescents (14-16 years) with obesity (BMI ≥ 95th percentile) who were recruited for a randomized controlled lifestyle intervention trial. Baseline data in youth (n = 148) who underwent a 2-hour OGTT was used to analyse agreement between WBISI and WBISI 120 . Data from 65 participants who completed a 12-week lifestyle intervention were used to assess changes and the rate of change between WBISI and WBISI 120 . Research costs to determine both measures were compared. WBISI 120 showed good cross-sectional agreement (ICC agreement = 0.88) with the full WBISI. Following intervention, WBISI 120 increased 62.5% (M ± SD, 1.6 ± 1.2 to 2.6 ± 1.7, P < .001) while WBISI increased by 25.0% (1.6 ± 1.0 to 2.0 ± 1.0, P < .001) but the rate of change for WBISI and WBISI 120 was not significantly different (P = .11). WBISI 120 costs ~70% less than WBISI. WBISI 120 may offer a cost-effective surrogate estimate of insulin sensitivity in Latino youth with obesity.
(© 2020 World Obesity Federation.)
Databáze: MEDLINE
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