Space-time clustering of childhood leukemia in Colombia: a nationwide study.

Autor: Rodriguez-Villamizar LA; Carrera 32 29-31 Of. 301 Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia. laurovi@uis.edu.co., Rojas Díaz MP; Instituto Nacional de Salud, Avenida 26 51-120, Bogotá, Colombia., Acuña Merchán LA; Ministerio de Salud y Protección Social, Cuenta de Alto Costo- Fondo Colombiano de Enfermedades de Alto Costo, Avenida 45 103-34 Of. 802, Bogota, Colombia., Moreno-Corzo FE; Observatorio de Salud Pública de Santander, Fundación Oftalmológica de Santander, Avenida El Bosque 23-60, Floridablanca, Colombia., Ramírez-Barbosa P; Ministerio de Salud y Protección Social, Cuenta de Alto Costo- Fondo Colombiano de Enfermedades de Alto Costo, Avenida 45 103-34 Of. 802, Bogota, Colombia.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2020 Jan 20; Vol. 20 (1), pp. 48. Date of Electronic Publication: 2020 Jan 20.
DOI: 10.1186/s12885-020-6531-2
Abstrakt: Background: Leukemia is the most common cancer in childhood. The estimated incidence rate of childhood leukemia in Colombia is one of the highest in America and little is known about its spatial distribution.
Purpose: To explore the presence of space-time clustering of childhood leukemia in Colombia.
Methods: We included children less than 15 years of age with confirmed diagnosis of acute leukemia reported to the national surveillance system for cancer between 2009 and 2017. Kulldorff's spatio-temporal scan statistics were used with municipality and year of diagnosis as units for spatial and temporal analysis.
Results: There were 3846 cases of childhood leukemia between 2009 and 2017 with a specific mean incidence rate of 33 cases per million person-years in children aged 0-14 years. We identified five spatial clusters of childhood leukemia in different regions of the country and specific time clustering during the study period.
Conclusion: Childhood leukemia seems to cluster in space and time in some regions of Colombia suggesting a common etiologic factor or conditions to be studied.
Databáze: MEDLINE
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