Multivariate analysis reveals anatomical correlates of naming errors in primary progressive aphasia.

Autor: Bruffaerts R; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium; Neurology Department, University Hospitals Leuven, Leuven, Belgium. Electronic address: rose.bruffaerts@kuleuven.be., Schaeverbeke J; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium., De Weer AS; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium., Nelissen N; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium., Dries E; Neurology Department, University Hospitals Leuven, Leuven, Belgium., Van Bouwel K; Neurology Department, University Hospitals Leuven, Leuven, Belgium., Sieben A; Neurology Department, University Hospital Ghent, Ghent, Belgium., Bergmans B; Neurology Department, University Hospital Ghent, Ghent, Belgium; Neurology Department, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium., Swinnen C; Neurology Department, H. Hartziekenhuis, Mol, Belgium., Pijnenburg Y; Neurology Department, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Sunaert S; Radiology Department, University Hospitals Leuven, Leuven, Belgium., Vandenbulcke M; Psychiatry Department, University Hospitals Leuven, Leuven, Belgium., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium; Neurology Department, University Hospitals Leuven, Leuven, Belgium.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2020 Apr; Vol. 88, pp. 71-82. Date of Electronic Publication: 2019 Dec 20.
DOI: 10.1016/j.neurobiolaging.2019.12.016
Abstrakt: Primary progressive aphasia (PPA) is an overarching term for a heterogeneous group of neurodegenerative diseases which affect language processing. Impaired picture naming has been linked to atrophy of the anterior temporal lobe in the semantic variant of PPA. Although atrophy of the anterior temporal lobe proposedly impairs picture naming by undermining access to semantic knowledge, picture naming also entails object recognition and lexical retrieval. Using multivariate analysis, we investigated whether cortical atrophy relates to different types of naming errors generated during picture naming in 43 PPA patients (13 semantic, 9 logopenic, 11 nonfluent, and 10 mixed variant). Omissions were associated with atrophy of the anterior temporal lobes. Semantic errors, for example, mistaking a rhinoceros for a hippopotamus, were associated with atrophy of the left mid and posterior fusiform cortex and the posterior middle and inferior temporal gyrus. Semantic errors and atrophy in these regions occurred in each PPA subtype, without major between-subtype differences. We propose that pathological changes to neural mechanisms associated with semantic errors occur across the PPA spectrum.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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