The role of elevated high-sensitivity cardiac troponin on outcomes following severe blunt chest trauma.

Autor: Keskpaik T; Department of Anesthesiology and Intensive Care, Tartu University Hospital, Estonia; Department of Anesthesiology and Intensive Care, Institute of Clinical Medicine, University of Tartu, Estonia. Electronic address: triinu.keskpaik@kliinikum.ee., Starkopf J; Department of Anesthesiology and Intensive Care, Tartu University Hospital, Estonia; Department of Anesthesiology and Intensive Care, Institute of Clinical Medicine, University of Tartu, Estonia. Electronic address: joel.starkopf@kliinikum.ee., Kirsimägi Ü; Department of Surgery, Institute of Clinical Medicine, University of Tartu, Estonia. Electronic address: ylle.kirsimagi@kliinikum.ee., Mihnovitš V; Department of Anesthesiology and Intensive Care, Tartu University Hospital, Estonia. Electronic address: vladislav.mihnovits@kliinikum.ee., Lomp A; Department of Anesthesiology and Intensive Care, Tartu University Hospital, Estonia. Electronic address: andrus.lomp@kliinikum.ee., Raamat EM; Department of Surgery, Tartu University Hospital, Estonia. Electronic address: eeva-maarja.raamat@ut.ee., Saar S; Department of Surgery, Institute of Clinical Medicine, University of Tartu, Estonia; Division of Acute Care Surgery, Department of Surgery, North Estonia Medical Centre, Estonia., Talving P; Department of Surgery, Institute of Clinical Medicine, University of Tartu, Estonia; Division of Acute Care Surgery, Department of Surgery, North Estonia Medical Centre, Estonia. Electronic address: peep.talving@ut.ee.
Jazyk: angličtina
Zdroj: Injury [Injury] 2020 May; Vol. 51 (5), pp. 1177-1182. Date of Electronic Publication: 2019 Dec 31.
DOI: 10.1016/j.injury.2019.12.037
Abstrakt: Background: Blunt cardiac injuries (BCI) result in poor outcomes following chest trauma. Admission ECG and troponin levels are frequently obtained in patients with suspected BCI, nevertheless, the prognostic value of cardiac troponins remains controversial. The purpose of the current study was to review the prognostic value of elevated high-sensitivity cardiac troponin T (hs-cTnT) in patients with severe blunt chest injuries. We hypothesized that elevated hs-cTnT result in poor outcomes in this subgroup of severe trauma patients.
Methods: After IRB approval, all consecutive patients with Injury Severity Score (ISS) > 15 and chest Abbreviated Injury Scale (AIS) score ≥3 admitted to the major trauma centers between 1/2015 and 6/2017 were retrospectively reviewed. Primary outcomes were in-hospital and one-year mortality. Secondary outcomes included ventilator days and Glasgow Outcome Scale (GOS) score at hospital discharge.
Results: Overall, 147 patients were included. Mean age was 49.0 (19.1) years and 75% were male. Serum troponin levels on admission were accrued in 82 (56%) patients with elevated and normal hs-cTnT levels found in 54 (66%) and in 28 (34%) patients, respectively. Elevated hs-cTnT group had significantly higher ISS and lactate level, and lower systolic blood pressure on admission. In-hospital mortality was significantly higher in patients with elevated hs-cTnT levels compared to patients with normal hs-cTnT levels (26% vs. 4%, p = 0.02). Hs-cTnT level > 14 ng/L was significantly associated with extended ventilator days and lower GOS score at hospital discharge.
Conclusion: Blunt chest trauma victims with elevated hs-cTnT levels experience significantly poorer adjusted outcomes compared to patients with normal levels. Compliance with EAST practice management guidelines following severe blunt chest trauma was not fully complied in our study cohort that warrants prospective performance improvement measures.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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