Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment.

Autor:	Cembran A; Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, ACT 2600, Australia., Bruggeman KF; Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, ACT 2600, Australia., Williams RJ; School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia., Parish CL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, VIC 3010, Australia. Electronic address: clare.parish@florey.edu.au., Nisbet DR; Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, ACT 2600, Australia. Electronic address: david.nisbet@anu.edu.au.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2020 Jan 24; Vol. 23 (1), pp. 100788. Date of Electronic Publication: 2019 Dec 19.
DOI:	10.1016/j.isci.2019.100788
Abstrakt:	The brain is a complex 3-dimensional structure, the organization of which provides a local environment that directly influences the survival, proliferation, differentiation, migration, and plasticity of neurons. To probe the effects of damage and disease on these cells, a synthetic environment is needed. Three-dimensional culturing of stem cells, neural progenitors, and neurons within fabricated biomaterials has demonstrated superior biomimetic properties over conventional 2-dimensional cultureware, offering direct recapitulation of both cell-cell and cell-extracellular matrix interactions. Within this review we address the benefits of deploying biomaterials as advanced cell culture tools capable of influencing neuronal fate and as in vitro models of the native in vivo microenvironment. We highlight recent and promising biomaterials approaches toward understanding neural network and their function relevant to neurodevelopment and provide our perspective on how these materials can be engineered and programmed to study both the healthy and diseased nervous system. (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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