Impact of Weight Loss on Inflammation State and Endothelial Markers Among Individuals with Extreme Obesity After Gastric Bypass Surgery: a 2-Year Follow-up Study.

Autor: Farias G; Gastrointestinal Surgery Service of Hospital de Clínicas, Federal University of Paraná, UFPR, Rua General Carneiro, 81 - Centro, Curitiba, PR, 80060-900, Brazil. gisele.nutri.farias@gmail.com., Netto BDM; Department of Nutrition, Federal University of Paraná, UFPR, Curitiba, PR, Brazil., Boritza K; Biochemistry Section, Hospital de Clínicas - Universidade Federal do Paraná, UFPR, Curitiba, PR, Brazil., Bettini SC; Gastrointestinal Surgery Service of Hospital de Clínicas, Federal University of Paraná, UFPR, Rua General Carneiro, 81 - Centro, Curitiba, PR, 80060-900, Brazil., Vilela RM; Department of Nutrition, Federal University of Paraná, UFPR, Curitiba, PR, Brazil., Dâmaso AR; Nutrition Post Graduate Program, Universidade Federal de São Paulo - Escola Paulista de Medicina - UNIFESP-EPM. Nutrition Post Graduate Program, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2020 May; Vol. 30 (5), pp. 1881-1890.
DOI: 10.1007/s11695-020-04411-9
Abstrakt: Background: The medium-term impact of gastric bypass (GB) surgery on the inflammatory state and endothelial function of patients has yet to be confirmed.
Objective: This study aims to elucidate the inflammatory profile and endothelial dysfunction response of adults with obesity 6 and 24 months after undergoing GB surgery.
Methods: The anthropometric and biochemical markers of 32 adults with obesity (two men and 30 females) were collected preoperatively, and 6 and 24 months postoperatively.
Results: Body mass index (BMI) and excess weight had decreased by 15.79 ± 1.21 kg/m 2 (p < 0.01) and 83.80 ± 24.50% respectively at 24 months. Leptin, C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1) levels, and the leptin/adiponectin ratio decreased significantly at both postoperative follow-up points compared with preoperative values (p < 0.01). IL-6 and ICAM-1 levels decreased between 6 and 24 months post-GB (p < 0.01). IL-6 and ICAM-1 levels decreased between 6- and 24-months post-GB (p < 0.01). Resistin levels were significantly decreased (p < 0.01) at 6-month follow-up. The levels of the anti-inflammatory biomarkers IL-10, adiponectin, and the adiponectin/leptin ratio significantly increased postoperatively. There was an improvement in metabolic disorders after surgery.
Conclusion: Our results demonstrated that after GB there was an improvement in the inflammatory profile, identified by a reduction in pro-inflammatory markers (CRP, IL-6, leptin) and an increase in anti-inflammatory markers (adiponectin, IL-10). The decrease in PAI-1 and ICAM-1 levels may suggest improvement in endothelial function. These findings provide clear evidence of the medium-term impact of GB on inflammation state and a number of endothelial markers, and a consequent reduction in the risk of cardiovascular diseases.
Databáze: MEDLINE
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