| Autor: |
Poppe K; Endocrine Unit; Departments of Université Libre de Bruxelles (ULB), Brussels, Belgium., Autin C; Gynecology, Obstetrics, and Reproductive Medicine Unit and Université Libre de Bruxelles (ULB), Brussels, Belgium., Veltri F; Endocrine Unit; Departments of Université Libre de Bruxelles (ULB), Brussels, Belgium., Sitoris G; Endocrine Unit; Departments of Université Libre de Bruxelles (ULB), Brussels, Belgium., Kleynen P; Endocrine Unit; Departments of Université Libre de Bruxelles (ULB), Brussels, Belgium., Praet JP; Internal Medicine; CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium., Rozenberg S; Gynecology, Obstetrics, and Reproductive Medicine Unit and Université Libre de Bruxelles (ULB), Brussels, Belgium. |
| Jazyk: |
angličtina |
| Zdroj: |
Thyroid : official journal of the American Thyroid Association [Thyroid] 2020 Aug; Vol. 30 (8), pp. 1177-1185. Date of Electronic Publication: 2020 Feb 18. |
| DOI: |
10.1089/thy.2019.0567 |
| Abstrakt: |
Background: The impact of thyroid disorders on in vitro outcomes of assisted reproductive technology (ART) remains controversial. Therefore, the aim of our study was to investigate whether thyroid peroxidase antibodies (TPO-Abs)/thyroid autoimmunity (TAI) or thyroid function (serum thyrotropin [TSH])/subclinical hypothyroidism are associated with an altered number of oocyte retrieval (NOR), fertilization rate (FR), and embryo quality (EQ). Methods: Cross-sectional study in 279 women in a single center, comprising 297 cycles and 1168 embryos. In vitro data (NOR, FR, and EQ) were documented in two groups; one according to thyroid function in women without TAI (TSH ≤2.5 and >2.5 mIU/L) and one according to the presence/absence of TAI (determined by TPO-Abs). EQ was evaluated according to international criteria and classified as excellent/good and poor. Women treated with levothyroxine (LT4) were excluded. Furthermore, the impact of thyroid parameters on outcomes, normal NOR (>6 or 8) and high FR (>60%), was verified in a multivariable logistic regression model. Results: In women without TAI, 27% had TSH levels >2.5 mIU/L, the prevalence of TAI was 8%, and overall, 6% of women had TSH levels >4.2 mIU/L. NOR, FR, and EQ were comparable between study groups. In the regression analysis, women aged ≥30 years and receiving a high ovarian stimulation dosage (>2300 IU/cycle) had lower rates of normal NOR (odds ratio [OR] 0.18 [95% confidence interval, CI 0.04-0.72]; p = 0.016 and OR 0.17 [CI 0.06-0.48]; p < 0.001, respectively). Conclusions: Our results do not suggest an impact of thyroid antibodies/autoimmunity and (dys)function on ART in vitro outcomes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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