Telomerase activity in the differential diagnosis of pancreatic mass.

Autor:	Karpova RV; Department of Surgery, No.1 of University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Levkin VV; Department of Surgery, No.1 of University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Degtyarevskaya TY; Department of Surgery, No.1 of University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Russkova KS; Department of Surgery, No.1 of University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Yushkevich AA; Department of Surgery, No.1 of University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Tevosyan AA; Department of Surgery, No.1 of University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Journal of gastrointestinal oncology [J Gastrointest Oncol] 2019 Dec; Vol. 10 (6), pp. 1094-1098.
DOI:	10.21037/jgo.2019.08.07
Abstrakt:	Background: In this manuscript, we show that the detection of telomerase activity in pancreatic mass tissue provides early evidence of a cancerous process that requires a well-timed surgical treatment. Methods: Eighty-eight patients with pancreatic mass (both benign and malignant) were involved in the research. Comparative analyses of the data and instrumental methods to define the histological structure of tumor mass and measure telomerase activity have been carried out. Results: Intense telomerase activity (+++) in the tissue of pancreatic mass determines cancer with high accuracy. One hundred percent of patients with pancreatic cancer had high telomerase activity. In 32.4% of patients with average telomerase activity (++) pancreatic cancer was diagnosed. The average telomerase activity (++) in pancreatic tumors gives an early indication of pancreatic cancer and requires dynamic observation for 6 to 12 months (P<0.05). Low telomerase activity (+) in patients with benign tumors is an accurate sign for confirming a diagnosis. Conclusions: The detection of telomerase activity in pancreatic mass tissue provides early evidence of a cancerous process that requires a well-timed surgical treatment. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare. (2019 Journal of Gastrointestinal Oncology. All rights reserved.)
Databáze:	MEDLINE
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