Slit3 regulates migration of endothelial progenitor cells by activation of the RhoA/Rho kinase pathway.

Autor:	Dou C; Medical College, Northwest University for Nationalities Lanzhou, China., Wang H; Department of Cardiology, Lanzhou University Second Hospital Lanzhou, China., Zhou G; Department of Cardiology, Gansu Provincial Hospital Lanzhou, China., Zhu H; Department of Cardiology, Gansu Provincial Hospital Lanzhou, China., Wen H; Department of Cardiology, Gansu Provincial Hospital Lanzhou, China., Xu S; Department of Cardiology, Gansu Provincial Hospital Lanzhou, China.
Jazyk:	angličtina
Zdroj:	International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2018 Jul 01; Vol. 11 (7), pp. 3398-3404. Date of Electronic Publication: 2018 Jul 01 (Print Publication: 2018).
Abstrakt:	Nerves and blood vessels are in close proximity, indicating possible biomolecular interactions. Slit/Robo signaling pathways play critical roles in cell proliferation and motility. Endothelial progenitor cells (EPCs) participate in angiogenesis and vascular homeostasis. EPC migration induced by Slit3 has not been fully characterized. Thus, the expression of Slit and Robo in EPCs was examined, and the chemotactic functions of Slit3 and the Slit/Robo signaling pathway regulatory mechanisms were explored. We observed that EPCs express mainly the Robo4 receptor, and its ligand Slit3 plays roles in regulation of EPCs migration through activating the RhoA/Rho related kinases. Regulation of Slit3/-Robo4 signaling in EPCs may provide a new therapeutic target for ischemic disease. Competing Interests: None. (IJCEP Copyright © 2018.)
Databáze:	MEDLINE
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